(Q27734002)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8939759%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

title

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design (English)

1 reference

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21 October 2019

2

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21 October 2019

author name string

R A Engh

1

1 reference

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21 October 2019

G Sucher

3

1 reference

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21 October 2019

A Eichinger

4

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21 October 2019

U Baumann

5

1 reference

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21 October 2019

W Bode

6

1 reference

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21 October 2019

R Huber

7

1 reference

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21 October 2019

T Poll

8

1 reference

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21 October 2019

R Rudolph

9

1 reference

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21 October 2019

W von der Saal

10

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21 October 2019

publication date

1 November 1996

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21 October 2019

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21 October 2019

volume

4

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21 October 2019

page(s)

1353-1362

1 reference

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21 October 2019

issue

11

1 reference

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 October 2019

cites work

1 reference

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7 January 2021

The clot thickens: clues provided by thrombin structure.

1 reference

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7 January 2021

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

1 reference

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7 January 2021

Structure of human des(1-45) factor Xa at 2.2 A resolution

1 reference

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7 January 2021

Coagulation factors and their inhibitors

1 reference

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7 January 2021

X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Thrombin active site inhibitors

1 reference

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7 January 2021

Rational design of hirulog-type inhibitors of thrombin

1 reference

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7 January 2021

The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity

1 reference

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7 January 2021

Conversion of thrombin into an anticoagulant by protein engineering

1 reference

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7 January 2021

The Na+ binding site of thrombin

1 reference

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7 January 2021

A novel factor Xa inhibitor: structure-activity relationships and selectivity between factor Xa and thrombin

1 reference

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7 January 2021

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

The coagulation cascade: initiation, maintenance, and regulation

1 reference

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7 January 2021

New antithrombotic strategies for resistant thrombotic processes

1 reference

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7 January 2021

Challenges in the development of orally bioavailable thrombin active site inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Correlation of binding affinities with non-bonded interaction energies of thrombin-inhibitor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Structure-based drug design

1 reference

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7 January 2021

The use of composite crystal-field environments in molecular recognition and the de novo design of protein ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Structure-based drug design: progress, results and challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Protein structure--based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Inhibition of bovine and human thrombins by derivatives of benzamidine

1 reference

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7 January 2021

Inhibition of bovine β-trypsin, human α-thrombin and porcine pancreatic β-kallikrein-B by 4′,6-diamidino-2-phenylindole, 6-amidinoindole and benzamidine: a comparative thermodynamic and X-ray structural study

1 reference

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7 January 2021

Internal water molecules and H‐bonding in biological macromolecules: A review of structural features with functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

(His)C epsilon-H...O=C < hydrogen bond in the active sites of serine hydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Buried water in homologous serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Water: now you see it, now you don't

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

The occurrence of C-H...O hydrogen bonds in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Stereochemical quality of protein structure coordinates

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900142-6

7 January 2021

10.1016/S0969-2126(96)00142-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8939759%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

1 reference