(Q27851446)

13 November 2016

title

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling (English)

1 reference

13 November 2016

1 reference

Qing-Bai She

1

Qing-Bai

She

1 reference

21 October 2023

Sarat Chandarlapaty

2

Sarat

Chandarlapaty

1 reference

21 October 2023

Qing Ye

3

Qing

Ye

1 reference

21 October 2023

Jose Lobo

4

Jose

Lobo

1 reference

21 October 2023

Kathleen M Haskell

5

Kathleen M

Haskell

1 reference

21 October 2023

Karen R Leander

6

Karen R

Leander

1 reference

21 October 2023

Deborah DeFeo-Jones

7

Deborah

DeFeo-Jones

1 reference

21 October 2023

Hans E Huber

8

Hans E

Huber

1 reference

21 October 2023

Neal Rosen

9

Neal

Rosen

1 reference

Creative Commons Attribution 4.0 International

21 October 2023

language of work or name

English

0 references

publication date

26 August 2008

0 references

published in

PLOS One

0 references

volume

3

0 references

issue

8

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page(s)

e3065

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copyright license

start time

26 August 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

AKT/PKB signaling: navigating downstream

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

20 March 2017

1 reference

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20 March 2017

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

20 March 2017

1 reference

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

20 March 2017

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

20 March 2017

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20 March 2017

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

20 March 2017

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High frequency of mutations of the PIK3CA gene in human cancers

20 March 2017

1 reference

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

20 March 2017

1 reference

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20 March 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

20 March 2017

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 April 2017

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

7 April 2017

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

7 April 2017

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The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

7 April 2017

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Oncogene addiction: setting the stage for molecularly targeted cancer therapy

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29 September 2017

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

29 September 2017

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

29 September 2017

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29 September 2017

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

29 September 2017

1 reference

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

29 September 2017

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

29 September 2017

1 reference

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

The PIK3CA gene is mutated with high frequency in human breast cancers.

29 September 2017

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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003065

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003065

Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003065

HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003065

Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0003065

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2516933

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18725974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Promoter methylation of the PTEN gene is a common molecular change in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18725974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0003065

1 reference

ADS bibcode

2008PLoSO...3.3065S

0 references

1 reference

1 reference

1 reference