(Q27851619)

13 November 2016

title

The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models (English)

1 reference

PubMed

PubMed publication ID

21258415

retaspimycin hydrochloride

13 November 2016

main subject

1 reference

non-small-cell lung carcinoma

ChEBI release 2020-05-28

ChEBI ID

71956

1 reference

E Normant

1

0 references

G Paez

2

0 references

K A West

3

0 references

A R Lim

4

0 references

K L Slocum

5

0 references

C Tunkey

6

0 references

J McDougall

7

0 references

A A Wylie

8

0 references

K Robison

9

0 references

K Caliri

10

0 references

V J Palombella

11

0 references

C C Fritz

Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.

12

0 references

language of work or name

English

0 references

publication date

2 June 2011

0 references

published in

Oncogene

0 references

volume

30

0 references

issue

22

0 references

page(s)

2581-6

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

HSP90 as a marker of progression in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Heat shock protein 90: the cancer chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

High HSP90 expression is associated with decreased survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Heat shock protein 90 inhibition in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

Hsp90: a specialized but essential protein-folding tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625

High-throughput oncogene mutation profiling in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.625