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Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane
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scholarly article
1 reference
stated in
PubMed
PubMed ID
9843581
retrieved
1 December 2016
title
Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane
(English)
1 reference
stated in
PubMed
PubMed ID
9843581
retrieved
1 December 2016
main subject
endoplasmic reticulum
0 references
Translocon subunit SEC61 YLR378C
1 reference
stated in
GOA release 2020-03-11
author
Randy Schekman
series ordinal
4
0 references
author name string
M Pilon
series ordinal
1
0 references
K Römisch
series ordinal
2
0 references
D Quach
series ordinal
3
0 references
language of work or name
English
0 references
publication date
December 1998
0 references
published in
Molecular Biology of the Cell
1 reference
stated in
PubMed
PubMed ID
9843581
retrieved
1 December 2016
volume
9
0 references
page(s)
3455-73
0 references
issue
12
0 references
cites work
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
Protein transport by purified yeast Sec complex and Kar2p without membranes
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PubMed Central
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20 March 2017
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1 reference
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PubMed Central
reference URL
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20 March 2017
ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
1 reference
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PubMed Central
reference URL
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20 March 2017
Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
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PubMed Central
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20 March 2017
Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
Evolutionary conservation of components of the protein translocation complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Getting started with yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Multifunctional yeast high-copy-number shuttle vectors
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Yeast/E. coli shuttle vectors with multiple unique restriction sites
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
A rapid method for localized mutagenesis of yeast genes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
20 March 2017
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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20 March 2017
In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
7 April 2017
The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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29 September 2017
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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29 September 2017
Determination of the transmembrane topology of yeast Sec61p, an essential component of the endoplasmic reticulum translocation complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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29 September 2017
Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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29 September 2017
Signal sequences specify the targeting route to the endoplasmic reticulum membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
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29 September 2017
Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
The Cs sec mutants of Escherichia coli reflect the cold sensitivity of protein export itself
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Temperature dependence of the hydrophobic interaction in protein folding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Mutations in the signal sequence of prepro-alpha-factor inhibit both translocation into the endoplasmic reticulum and processing by signal peptidase in yeast cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
29 September 2017
Protein translocation: tunnel vision
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
2 June 2018
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
2 June 2018
Sec61p and BiP directly facilitate polypeptide translocation into the ER.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
2 June 2018
Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
2 June 2018
Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25656
retrieved
27 November 2018
A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9843581
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9843581
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9843581
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9843581
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Yeast protein translocation complex: Isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61β subunit
1 reference
stated in
COCI
retrieved
12 October 2022
reference URL
https://opencitations.net/index/coci/api/v1/references/10.1091/MBC.9.12.3455
Identifiers
DOI
10.1091/MBC.9.12.3455
0 references
PMCID
25656
0 references
PubMed ID
9843581
1 reference
stated in
PubMed
PubMed ID
9843581
retrieved
1 December 2016
ResearchGate publication ID
13443317
0 references
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