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Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
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scholarly article
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stated in
PubMed
title
Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
(English)
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stated in
PubMed
main subject
pathogenesis
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based on heuristic
inferred from title
microRNA
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based on heuristic
inferred from title
osteoarthritis
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based on heuristic
inferred from title
author name string
Fu-xing PEI
series ordinal
1
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
March 2016
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stated in
PubMed
published in
Journal of Zhejiang University. Science. B
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stated in
PubMed
volume
17
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stated in
PubMed
issue
3
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PubMed
page(s)
200-8
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stated in
PubMed
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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors
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miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1
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NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
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Nuclear export of microRNA precursors
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The nuclear RNase III Drosha initiates microRNA processing
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Role for a bidentate ribonuclease in the initiation step of RNA interference
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Biochemical characterization of human collagenase-3
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Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
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20 March 2017
SOX9 directly regulates the type-II collagen gene
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PubMed Central
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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
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20 March 2017
Sox9 is required for cartilage formation
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PubMed Central
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The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
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Developmental regulation of the growth plate
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Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration
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Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers
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29 September 2017
Deregulation of microRNA expression in thyroid tumors
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PubMed Central
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29 September 2017
MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes
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29 September 2017
Clinical and laboratory characteristics of patients having amyloidogenic transthyretin deposition in osteoarthritic knee joints
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29 September 2017
The NF-κB signalling pathway in osteoarthritis
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PubMed Central
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29 September 2017
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes
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PubMed Central
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29 September 2017
Macro view of microRNA function in osteoarthritis
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PubMed Central
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29 September 2017
MicroRNAs: potentially important regulators for schistosome development and therapeutic targets against schistosomiasis
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29 September 2017
MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1β-stimulated human articular chondrocyte C28/I2 cells
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PubMed Central
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29 September 2017
The expression and function of microRNAs in chondrogenesis and osteoarthritis.
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PubMed Central
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29 September 2017
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)
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PubMed Central
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29 September 2017
MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation.
1 reference
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PubMed Central
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29 September 2017
MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Age-dependent alteration of TGF-β signalling in osteoarthritis
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PubMed Central
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29 September 2017
Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.
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PubMed Central
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29 September 2017
Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
MicroRNA-140 and the silencing of osteoarthritis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
MicroRNA-140 plays dual roles in both cartilage development and homeostasis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
The NF-kappaB family of transcription factors and its regulation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Recent developments in patent anti-cancer agents targeting the matrix metalloproteinases (MMPs).
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PubMed Central
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29 September 2017
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
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PubMed Central
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29 September 2017
MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
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PubMed Central
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29 September 2017
SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Smad3 activates the Sox9-dependent transcription on chromatin
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
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PubMed Central
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29 September 2017
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Treatment of osteoarthritis with acetaminophen: efficacy, safety, and comparison with nonsteroidal anti-inflammatory drugs
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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29 September 2017
Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
Tumor Necrosis Factor α-Induced MicroRNA-18a Activates Rheumatoid Arthritis Synovial Fibroblasts Through a Feedback Loop in NF-κB Signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794511
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27 November 2018
Activation of Akt leading to NF-κB up-regulation in chondrocytes stimulated with fibronectin fragment
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
mRNA expression profiling reveals conserved and non-conserved miR-140 targets
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MicroRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1β-induced catabolic effects in human chondrocytes
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Immunological analysis of proteoglycan structural changes in the early stage of experimental osteoarthritic canine cartilage lesions
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Osteoarthritis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26984840
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1631/JZUS.B1500267
0 references
Dimensions Publication ID
1022742205
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PMCID
4794511
1 reference
stated in
PubMed
PubMed ID
26984840
1 reference
stated in
PubMed
Springer Nature article ID
10.1631/jzus.b1500267
0 references
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