(Q28074434)

title

Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis (English)

1 reference

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hepatocellular carcinoma

1 reference

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Juan-Ramón Larrubia

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Elia Moreno-Cubero

series ordinal

1

1 reference

Juan-Ramón Larrubia

series ordinal

2

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language of work or name

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28 July 2016

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World Journal of Gastroenterology

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

22

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

28

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

6469-6483

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48

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Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes

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CD28/B7 system of T cell costimulation

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Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes

20 March 2017

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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LAG-3, a novel lymphocyte activation gene closely related to CD4

20 March 2017

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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

20 March 2017

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CD28 and CTLA-4 coreceptor expression and signal transduction

20 March 2017

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Reversal of the TCR stop signal by CTLA-4

20 March 2017

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Restoring function in exhausted CD8 T cells during chronic viral infection

20 March 2017

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

20 March 2017

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Identification of the 2B4 molecule as a counter-receptor for CD48

20 March 2017

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

20 March 2017

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Enhancement of antitumor immunity by CTLA-4 blockade

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20 March 2017

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A new member of the immunoglobulin superfamily--CTLA-4

20 March 2017

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20 March 2017

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Hepatocellular carcinoma

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Analysis of a successful immune response against hepatitis C virus

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

7 April 2017

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New therapies for chronic hepatitis B.

7 April 2017

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Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation

29 September 2017

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Hepatic Stellate Cells Inhibit T Cells through Active TGF-β1 from a Cell Surface-Bound Latent TGF-β1/GARP Complex

29 September 2017

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Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+ T cells

29 September 2017

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The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors

29 September 2017

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Confusing signals: recent progress in CTLA-4 biology

29 September 2017

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Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes

29 September 2017

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Immunopathogenesis of chronic hepatitis B.

29 September 2017

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Update on hepatitis B virus infection

29 September 2017

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CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals.

29 September 2017

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Adaptive immune response during hepatitis C virus infection.

29 September 2017

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Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

29 September 2017

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Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma

29 September 2017

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Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

29 September 2017

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Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

29 September 2017

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Epidemiology and natural history of HCV infection.

29 September 2017

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29 September 2017

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Longitudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B.

29 September 2017

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PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model

29 September 2017

1 reference

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Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B.

29 September 2017

1 reference

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Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection

29 September 2017

1 reference

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Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

29 September 2017

1 reference

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

29 September 2017

1 reference

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Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

29 September 2017

1 reference

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Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model

29 September 2017

1 reference

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

29 September 2017

1 reference

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Phenotype and function of human T lymphocyte subsets: consensus and issues

29 September 2017

1 reference

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Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors

29 September 2017

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Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help

29 September 2017

1 reference

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Immunobiology and pathogenesis of viral hepatitis

29 September 2017

1 reference

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PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Induction of tolerance in CD8+ T cells to a transgenic autoantigen expressed in the liver does not require cross-presentation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Immunology: how do T cells recognize antigen?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Dendritic cells and immune regulation in the liver

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

New regulatory co-receptors: inducible co-stimulator and PD-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Hepatoimmunology: a perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Bone Marrow Origin of Hepatic Macrophages (Kupffer Cells) in Humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Ablation of persistent hepatitis B by bone marrow transplantation from a hepatitis B-immune donor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection

2 June 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Exhausted or just sleeping: awakening virus-specific responses in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Diagnosis and Treatment of Hepatocellular Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1(+)/CD127(-) HCV-specific CD8(+) cells targeting the virus in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Hepatic allograft-derived Kupffer cells regulate T cell response in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8(+) T cell in HCC patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Blockade of Tim-3 signaling restores the virus-specific CD8⁺ T-cell response in patients with chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.3748%2FWJG.V22.I28.6469

B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968127

Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma

27 November 2018

1 reference

12 December 2020

Intermittence of blood flow in liver sinusoids, studied by high-resolution in vivo microscopy

1 reference

12 December 2020

Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

1 reference

12 December 2020

Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin-10 through membrane-bound TGF-β

1 reference

12 December 2020

CD3+ WT31- peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the alpha/beta heterodimer

1 reference

12 December 2020

EASL Clinical Practice Guidelines: management of hepatitis C virus infection

1 reference

12 December 2020

Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo

1 reference

12 December 2020

Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance?

1 reference

12 December 2020

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

1 reference

12 December 2020

Antigen-specific primary activation of CD8+ T cells within the liver

1 reference

12 December 2020

T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells

1 reference

12 December 2020

Identifiers

DOI

10.3748/WJG.V22.I28.6469

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27605882%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

2 references