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TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity
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title
TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity
(English)
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PubMed
author name string
Jennifer D Stone
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1
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Crossref
Daniel T Harris
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2
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Crossref
David M Kranz
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3
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language of work or name
English
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PubMed
publication date
April 2015
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PubMed
published in
Current Opinion in Immunology
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PubMed
volume
33
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PubMed
page(s)
16-22
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PubMed
cites work
TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms
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Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor
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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
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20 March 2017
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation
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PubMed Central
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Cancer regression in patients after transfer of genetically engineered lymphocytes
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20 March 2017
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
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20 March 2017
The molecular basis of TCR germline bias for MHC is surprisingly simple
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Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
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7 April 2017
How TCRs bind MHCs, peptides, and coreceptors
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7 April 2017
Revisiting thymic positive selection and the mature T cell repertoire for antigen
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29 September 2017
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control
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29 September 2017
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies
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29 September 2017
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes
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29 September 2017
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
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29 September 2017
Unravelling the mechanisms of durable control of HIV-1.
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29 September 2017
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
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PubMed Central
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29 September 2017
Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection
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PubMed Central
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29 September 2017
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity
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29 September 2017
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
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29 September 2017
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
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PubMed Central
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29 September 2017
Cross-reactivity of T cells and its role in the immune system
1 reference
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PubMed Central
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29 September 2017
Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses
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PubMed Central
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29 September 2017
Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies
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29 September 2017
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
1 reference
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PubMed Central
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29 September 2017
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
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29 September 2017
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity
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PubMed Central
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29 September 2017
T cell receptor engineering
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PubMed Central
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29 September 2017
A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.
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PubMed Central
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29 September 2017
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection
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29 September 2017
Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice
1 reference
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PubMed Central
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29 September 2017
The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research
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PubMed Central
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29 September 2017
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity
1 reference
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PubMed Central
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29 September 2017
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness
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PubMed Central
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29 September 2017
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions
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PubMed Central
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29 September 2017
Evolutionarily conserved amino acids that control TCR-MHC interaction
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PubMed Central
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29 September 2017
High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920053
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29 September 2017
Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes
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PubMed Central
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29 September 2017
Display, engineering, and applications of antigen-specific T cell receptors
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29 September 2017
CD4 cells can be more efficient at tumor rejection than CD8 cells
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PubMed Central
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29 September 2017
Making high-affinity T-cell receptors: a new class of targeted therapeutics.
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29 September 2017
TCRs with high affinity for foreign pMHC show self-reactivity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920053
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29 September 2017
Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice.
1 reference
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PubMed Central
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29 September 2017
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy
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PubMed Central
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29 September 2017
Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules.
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PubMed Central
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29 September 2017
Targeting p53 as a general tumor antigen
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PubMed Central
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29 September 2017
Positive selection of thymocytes
1 reference
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PubMed Central
reference URL
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29 September 2017
Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex
1 reference
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PubMed Central
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2 June 2018
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
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PubMed Central
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27 November 2018
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
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27 November 2018
Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4920053
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27 November 2018
Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands
1 reference
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PubMed Central
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27 November 2018
T cell killing does not require the formation of a stable mature immunological synapse.
1 reference
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PubMed Central
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27 November 2018
Direct observation of ligand recognition by T cells.
1 reference
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27 November 2018
Integrated functional genomics approach for the design of patient-individual antitumor vaccines.
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27 November 2018
Targeting self-antigens through allogeneic TCR gene transfer
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25618219
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A very high level of crossreactivity is an essential feature of the T-cell receptor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25618219
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25618219
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25618219
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25618219
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.COI.2015.01.003
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4984723
OpenCitations bibliographic resource ID
4984723
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4984723
PMCID
4920053
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4984723
PubMed ID
25618219
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4984723
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