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NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
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title
NKG2D Ligands in Tumor Immunity: Two Sides of a Coin
(English)
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PubMed
author name string
Jinyu Zhang
series ordinal
1
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Crossref
Fahmin Basher
series ordinal
2
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stated in
Crossref
Jennifer D. Wu
series ordinal
3
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language of work or name
English
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PubMed
publication date
4 March 2015
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published in
Frontiers in Immunology
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volume
6
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PubMed
page(s)
97
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PubMed
cites work
Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
1 reference
stated in
PubMed Central
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20 March 2017
Tumor-associated MICA is shed by ADAM proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349182
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20 March 2017
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349182
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20 March 2017
Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349182
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20 March 2017
ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
1 reference
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PubMed Central
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20 March 2017
Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
1 reference
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PubMed Central
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20 March 2017
An activating immunoreceptor complex formed by NKG2D and DAP10
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PubMed Central
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20 March 2017
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
1 reference
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PubMed Central
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20 March 2017
Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
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PubMed Central
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20 March 2017
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349182
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20 March 2017
Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
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PubMed Central
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20 March 2017
A multigene family on human chromosome 12 encodes natural killer-cell lectins
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PubMed Central
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20 March 2017
DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
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20 March 2017
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
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20 March 2017
Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?
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20 March 2017
A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D
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20 March 2017
Expansion of NK cells and reduction of NKG2D expression in chronic lymphocytic leukemia. Correlation with progressive disease
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29 September 2017
Molecular Bases for the Regulation of NKG2D Ligands in Cancer.
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29 September 2017
Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance.
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29 September 2017
Advances in NKG2D ligand recognition and responses by NK cells
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29 September 2017
Regulation of mouse NK cell development and function by cytokines
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29 September 2017
Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis
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29 September 2017
Regulation of ligands for the NKG2D activating receptor
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29 September 2017
NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study
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29 September 2017
Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation
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PubMed Central
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29 September 2017
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases
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29 September 2017
An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding
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PubMed Central
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29 September 2017
Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress
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PubMed Central
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29 September 2017
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein
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29 September 2017
Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs
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29 September 2017
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D.
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29 September 2017
Human tumor-derived exosomes down-modulate NKG2D expression.
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PubMed Central
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29 September 2017
NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells.
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29 September 2017
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
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29 September 2017
Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation
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29 September 2017
Upregulation of MICA on high-grade invasive operable breast carcinoma
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29 September 2017
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.
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29 September 2017
Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.
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29 September 2017
IL-2/IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun N-terminal kinase (JNK) pathway
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29 September 2017
Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity
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29 September 2017
NKG2D splice variants: a reexamination of adaptor molecule associations
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29 September 2017
IFN-dependent down-regulation of the NKG2D ligand H60 on tumors
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29 September 2017
Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells
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29 September 2017
NKG2D function protects the host from tumor initiation
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29 September 2017
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
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29 September 2017
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
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29 September 2017
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
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29 September 2017
Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells
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29 September 2017
Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma
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29 September 2017
MICA/NKG2D-mediated immunogene therapy of experimental gliomas.
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29 September 2017
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
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29 September 2017
Roles of the NKG2D immunoreceptor and its ligands
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29 September 2017
Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
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29 September 2017
The role of the NKG2D immunoreceptor in immune cell activation and natural killing
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29 September 2017
T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells
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29 September 2017
Tumor cell recognition by natural killer cells
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29 September 2017
NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
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29 September 2017
Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
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29 September 2017
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
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29 September 2017
Enhancement of CD8+ T cell responses by ICOS/B7h costimulation
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29 September 2017
Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D.
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29 September 2017
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
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29 September 2017
Isolation and characterization of NK cell or NK/T cell-specific cDNA clones
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29 September 2017
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
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2 June 2018
IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
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2 June 2018
In-vitro activation of natural killer cells from regional lymph nodes of melanoma patients with interleukin-2 and interleukin-15.
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27 November 2018
Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention.
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27 November 2018
Soluble MICB in malignant diseases: analysis of diagnostic significance and correlation with soluble MICA
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27 November 2018
Proteolytic release of soluble UL16-binding protein 2 from tumor cells
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27 November 2018
Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients.
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PubMed Central
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27 November 2018
Soluble MICA in malignant diseases
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27 November 2018
Licensing of natural killer cells by host major histocompatibility complex class I molecules
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27 November 2018
NKG2D is a costimulatory receptor for human naive CD8+ T cells.
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27 November 2018
A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease.
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27 November 2018
Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
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27 November 2018
Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349182
retrieved
27 November 2018
IL-15 is an essential mediator of peripheral NK-cell homeostasis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CD4+NKG2D+ T Cells in Crohn’s Disease Mediate Inflammatory and Cytotoxic Responses Through MICA Interactions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tumor-derived soluble MICs impair CD3(+)CD56(+) NKT-like cell cytotoxicity in cancer patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of stress-induced MHC class I related chain molecules on human melanoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25788898
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FIMMU.2015.00097
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3528023
OpenCitations bibliographic resource ID
3528023
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3528023
PMC publication ID
4349182
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3528023
PubMed publication ID
25788898
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3528023
ResearchGate publication ID
273781606
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