(Q28114955)

English

Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa

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scholarly article

2 references

3 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9169594%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa (English)

2 references

3 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9169594%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Coagulation factor XI

1 reference

GOA release 2020-03-11

coagulation factor IX

1 reference

GOA release 2020-03-11

blood coagulation

1 reference

GOA release 2020-03-11

author name string

E G Wojcik

1

1 reference

Europe PubMed Central

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3 November 2019

M Van Den Berg

2

1 reference

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3 November 2019

S R Poort

3

1 reference

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3 November 2019

R M Bertina

4

1 reference

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3 November 2019

language of work or name

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publication date

1 May 1997

2 references

3 January 2017

Europe PubMed Central

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3 November 2019

Biochemical Journal

2 references

3 January 2017

Europe PubMed Central

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3 November 2019

323 ( Pt 3)

2 references

3 January 2017

Europe PubMed Central

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3 November 2019

629-636

1 reference

Europe PubMed Central

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3 November 2019

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

The molecular basis of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

7 April 2017

PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

Nucleotide sequence of the gene for human factor IX (antihemophilic factor B)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

20 March 2017

Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

7 April 2017

Recurrent mutations in the factor IX gene: founder effect or repeat de novo events. Investigation of the German haemophilia B population and review of de novo mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

29 September 2017

The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

29 September 2017

The propeptide region of clotting factor IX is a signal for a vitamin K dependent carboxylase: evidence from protein engineering of amino acid -4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

29 September 2017

Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

29 September 2017

Protein engineering of the propeptide of human factor IX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

29 September 2017

Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with alpha 1-microglobulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Intracellular maturation of the gamma-carboxyglutamic acid (Gla) region in prothrombin coincides with release of the propeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Factor IX Zutphen: a Cys18-->Arg mutation results in formation of a heterodimer with alpha 1-microglobulin and the inability to form a calcium-induced conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Chemical modification of prothrombin fragment 1: documentation of sequential, two-stage loss of protein function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

The factor IX phospholipid-binding site is required for calcium-dependent activation of factor IX by factor XIa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position -4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Defective propeptide processing and abnormal activation underlie the molecular pathology of factor IX Troed-y-Rhiw

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Factor IX Kawachinagano: impaired function of the Gla-domain caused by attached propeptide region due to substitution of arginine by glutamine at position -4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Vitamin K-dependent carboxylation. In vitro modification of synthetic peptides containing the gamma-carboxylation recognition site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic acid domain of coagulation factor IX. Effect of mutations near the propeptide cleavage site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Factor IX mutations: rapid, direct screening methods for 20 new families with hemophilia B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

2 June 2018

Thrombotic risk in hereditary antithrombin III, protein C, or protein S deficiency. A cooperative, retrospective study. Gesellschaft fur Thrombose- und Hamostaseforschung (GTH) Study Group on Natural Inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218364

27 November 2018

Membrane binding properties of the factor IX gamma-carboxyglutamic acid-rich domain prepared by chemical synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of propeptide in vitamin K-dependent gamma-carboxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of six mutations of the protein C gene on the Gla domain conformation and calcium affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of factor IX: implications for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein C Osaka 10 with aberrant propeptide processing: loss of anticoagulant activity due to an amino acid substitution in the protein C precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of amino groups in inhibitors of proteolytic enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagents

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood coagulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of factor IX in tissue thromboplastin induced coagulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Horseradish peroxidase: kinetic studies and optimization of peroxidase activity determination using the substrates H2O2 and 3,3',5,5'-tetramethylbenzidine]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rabbit polyclonal antibodies against the calcium-dependent conformation of factor IX and their application in solid phase immunoradiometric assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition site directing vitamin K-dependent gamma-carboxylation resides on the propeptide of factor IX

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of propeptide mutations on post-translational processing of factor IX. Evidence that beta-hydroxylation and gamma-carboxylation are independent events

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminal alanine functions in a calcium-specific process essential for membrane binding by prothrombin fragment 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of Ca2+ prothrombin fragment 1 including the conformation of the Gla domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two mutations of the factor IX gene including a donor splice consensus deletion and a point mutation in a Dutch patient with severe hemophilia B

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modifications of bovine prothrombin fragment 1 in the presence and absence of Ca(II) ions. Loss of positive cooperativity in Ca(II) ion binding for the modified proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profactor IX: the propeptide inhibits binding to membrane surfaces and activation by factor XIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/9169594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3230629

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9169594%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9169594%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

2 references

3 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9169594%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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