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Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
scientific journal article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
title
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
(English)
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
main subject
Gem nuclear organelle associated protein 5
1 reference
stated in
GOA release 2020-03-11
DEAD-box helicase 20
1 reference
stated in
GOA release 2020-03-11
Gem nuclear organelle associated protein 4
1 reference
stated in
GOA release 2020-03-11
Gem nuclear organelle associated protein 2
1 reference
stated in
GOA release 2020-03-11
Gem nuclear organelle associated protein 7
1 reference
stated in
GOA release 2020-03-11
Gem nuclear organelle associated protein 6
1 reference
stated in
GOA release 2020-03-11
Serine/threonine kinase receptor associated protein
1 reference
stated in
GOA release 2020-03-11
Survival of motor neuron 2, centromeric
1 reference
stated in
GOA release 2020-03-11
author name string
Jeongsik Yong
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
Mumtaz Kasim
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
Jennifer L. Bachorik
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
Lili Wan
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
Gideon Dreyfuss
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
publication date
28 May 2010
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
published in
Molecular Cell
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stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
volume
38
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stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
page(s)
551–562
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stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
issue
4
1 reference
stated in
PubMed
PubMed ID
20513430
retrieved
4 January 2017
cites work
Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The Gemin5 protein of the SMN complex identifies snRNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Mfold web server for nucleic acid folding and hybridization prediction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
pICln inhibits snRNP biogenesis by binding core spliceosomal proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The SMN complex, an assemblyosome of ribonucleoproteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
A novel WD repeat protein component of the methylosome binds Sm proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Spliceosomal UsnRNP biogenesis, structure and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
A novel nuclear structure containing the survival of motor neurons protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Unrip is a component of SMN complexes active in snRNP assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Why do cells need an assembly machine for RNA-protein complexes?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Characterization of Heterogeneous Nuclear RNA-Protein Complexes In Vivo with Monoclonal Antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
20 March 2017
Identification and characterization of a spinal muscular atrophy-determining gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
7 April 2017
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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7 April 2017
The assembly of a spliceosomal small nuclear ribonucleoprotein particle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Inactivation of the SMN complex by oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Analysis of protein complexes using mass spectrometry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
snRNAs contain specific SMN-binding domains that are essential for snRNP assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Splicing double: insights from the second spliceosome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Essential role for the SMN complex in the specificity of snRNP assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Sequence-specific interaction of U1 snRNA with the SMN complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Correlation between severity and SMN protein level in spinal muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
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29 September 2017
Precursors of U4 small nuclear RNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Accurate and efficient 3' processing of U2 small nuclear RNA precursor in a fractionated cytoplasmic extract
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Initiation and termination of human U1 RNA transcription requires the concerted action of multiple flanking elements
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
Nuclear processing of the 3'-terminal nucleotides of pre-U1 RNA in Xenopus laevis oocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
29 September 2017
A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
27 November 2018
U2 small nuclear RNA 3' end formation is directed by a critical internal structure distinct from the processing site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2901871
retrieved
27 November 2018
Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20513430
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Spinal muscular atrophy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20513430
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Gemins modulate the expression and activity of the SMN complex
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20513430
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLCEL.2010.03.014
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4183093
OpenCitations bibliographic resource ID
4183093
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4183093
PMCID
2901871
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4183093
PubMed ID
20513430
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4183093
ResearchGate publication ID
44640583
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