(Q28139333)

1

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R M Kohli

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H D Mootz

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M A Marahiel

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C T Walsh

Harnessing the biosynthetic code: combinations, permutations, and mutations

5

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language of work or name

English

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publication date

14 September 2000

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published in

Nature

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volume

407

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page(s)

215-8

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issue

6801

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cites work

1 reference

7 January 2021

Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

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7 January 2021

A new enzyme superfamily - the phosphopantetheinyl transferases

1 reference

7 January 2021

Structure of a myristoyl-ACP-specific thioesterase from Vibrio harveyi

1 reference

7 January 2021

Conversion of serine-114 to cysteine-114 and the role of the active site nucleophile in acyl transfer by myristoyl-ACP thioesterase from Vibrio harveyi

1 reference

7 January 2021

Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization.

1 reference

7 January 2021

The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

1 reference

7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

1 reference

7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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7 January 2021

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

1 reference

7 January 2021

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

1 reference

7 January 2021

Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

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7 January 2021

Alternative modular polyketide synthase expression controls macrolactone structure

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7 January 2021

Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains

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7 January 2021

Engineering of peptide synthetases. Key role of the thioesterase-like domain for efficient production of recombinant peptides

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7 January 2021

Construction of hybrid peptide synthetases by module and domain fusions

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7 January 2021

Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis

1 reference

7 January 2021

The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains

1 reference

7 January 2021

Isolation of enzyme-bound peptide intermediates in tyrocidine biosynthesis

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7 January 2021

Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene

1 reference

7 January 2021

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes

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7 January 2021

A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues

1 reference

7 January 2021