(Q28139368)

English

Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants

scientific article (publication date: December 1999)

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scholarly article

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Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants (English)

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author name string

S Masure

1

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H Geerts

2

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M Cik

3

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E Hoefnagel

4

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G Van Den Kieboom

5

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A Tuytelaars

6

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S Harris

7

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A S Lesage

8

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J E Leysen

9

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L Van Der Helm

10

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P Verhasselt

11

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J Yon

12

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R D Gordon

13

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language of work or name

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publication date

December 1999

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266

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3

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892-902

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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

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GDNF is an age-specific survival factor for sensory and autonomic neurons

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Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells

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Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

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Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

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Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

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Functional recovery in parkinsonian monkeys treated with GDNF

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Dopaminergic neurons protected from degeneration by GDNF gene therapy

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Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

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Neurturin, a relative of glial-cell-line-derived neurotrophic factor

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Persephin, a novel neurotrophic factor related to GDNF and neurturin

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Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

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GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

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Characterization of a multicomponent receptor for GDNF.

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Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

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TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

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A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

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Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.

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GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family

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Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)

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Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family

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Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor

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GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family

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GFRalpha-4, a new GDNF family receptor

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GDNF signalling through the Ret receptor tyrosine kinase

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Functional receptor for GDNF encoded by the c-ret proto-oncogene

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Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

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Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase

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GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

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Basic local alignment search tool

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Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

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Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway

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Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products

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Novel structure of the human GDNF gene

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Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3

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The scanning model for translation: an update

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GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells

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Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

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Mutations of the RET proto-oncogene in Hirschsprung's disease

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Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient

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Renal agenesis and the absence of enteric neurons in mice lacking GDNF

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Renal and neuronal abnormalities in mice lacking GDNF

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Defects in enteric innervation and kidney development in mice lacking GDNF

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GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney

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GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

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Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

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Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

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Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines

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Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence

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Paclitaxel (taxol)

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