(Q28142088)

English

A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase

scientific article (publication date: 30 April 1999)

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scholarly article

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A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase (English)

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author name string

A N Hanna

1

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E Y Chan

2

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J Xu

3

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J C Stone

4

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D N Brindley

5

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language of work or name

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publication date

30 April 1999

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Journal of Biological Chemistry

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274

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18

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12722-9

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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation

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Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.

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Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis

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Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation

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Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

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Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

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Tumor necrosis factor-alpha regulation of glucose transporter (GLUT1) mRNA turnover. Contribution of the 3'-untranslated region of the GLUT1 message

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21 January 2018

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

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Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

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Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes

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Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells

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Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN

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Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase

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Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Phosphoinositide kinases

1 reference

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

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Phosphatidylinositol 3-kinase

1 reference

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Role of PI 3-kinase in mitogenesis

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

1 reference

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Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

1 reference

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The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

1 reference

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Rho Family GTPases Bind to Phosphoinositide Kinases

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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Normal rat cell lines deficient in nuclear thymidine kinase

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Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

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A simple, rapid, and sensitive DNA assay procedure

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Cell cycle-dependent activation of Ras.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

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Association of p21ras with phosphatidylinositol 3-kinase

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21 January 2018

Agonist-induced association of the p21ras GTPase-activating protein with phosphatidylinositol 3-kinase

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Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways

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Phosphorylation of Raf by ceramide-activated protein kinase

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Ceramide: a signal for apoptosis or mitogenesis?

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21 January 2018

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10.1074/JBC.274.18.12722

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