(Q28142403)

English

Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes

scientific article (publication date: 26 January 2001)

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scholarly article

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Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes (English)

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author name string

Y Miyakawa

1

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P Rojnuckarin

2

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T Habib

3

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K Kaushansky

4

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language of work or name

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publication date

26 January 2001

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Journal of Biological Chemistry

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276

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4

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2494-502

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Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Thrombocytopenia in c-mpl-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Thrombopoietin signal transduction requires functional JAK2, not TYK2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Protein kinase C and c-myc gene activation pathways in thrombopoietin signal transduction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Interleukin 3-dependent survival by the Akt protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Engagement of Gab1 and Gab2 in erythropoietin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002633200

21 January 2018

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10.1074/JBC.M002633200

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