(Q28145614)

English

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

scientific article (publication date: October 1999)

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Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure (English)

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substantia nigra

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based on heuristic

inferred from title

author name string

J W Langston

1

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L S Forno

2

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J Tetrud

3

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A G Reeves

4

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J A Kaplan

5

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D Karluk

6

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language of work or name

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publication date

October 1999

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Annals of Neurology

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46

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598-605

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4

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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21 January 2018

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

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21 January 2018

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1 reference

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21 January 2018

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

1 reference

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21 January 2018

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1 reference

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21 January 2018

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism.

1 reference

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21 January 2018

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

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21 January 2018

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

1 reference

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21 January 2018

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

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Parkinson disease in twins: an etiologic study

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21 January 2018

Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases

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Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1 reference

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Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region

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Motor neuron disease on Guam: geographic and familial occurrence, 1956-85.

1 reference

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Amyotrophic lateral sclerosis among Chamorro migrants from Guam

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21 January 2018

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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21 January 2018

Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease

1 reference

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21 January 2018

Positron emission tomographic evidence for progression of human MPTP-induced dopaminergic lesions

1 reference

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A radical hypothesis for neurodegeneration

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The free radical hypothesis in idiopathic parkinsonism: evidence against it

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21 January 2018

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

1 reference

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21 January 2018

TGFbeta1 and TGFbeta2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid.

1 reference

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21 January 2018

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease.

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Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients.

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21 January 2018

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

1 reference

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21 January 2018

Identifiers

10.1002/1531-8249(199910)46:4<598::AID-ANA7>3.0.CO;2-F

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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