(Q28185990)

English

Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells

scientific article (publication date: 2004)

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Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells (English)

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Human T-lymphotropic virus 1

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author name string

Jihua Cheng

1

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Dongsheng Zhang

2

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Changhong Zhou

3

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Wayne A Marasco

4

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language of work or name

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publication date

January 2004

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Leukemia Research

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28

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1

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71-82

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Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP).

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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

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Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

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Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells

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Signaling from the IL-2 receptor to the nucleus.

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Role of phosphatases in lymphocyte activation.

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Cytokine signaling: cytokine-inducible signaling inhibitors

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The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

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A family of cytokine-inducible inhibitors of signalling

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A new protein containing an SH2 domain that inhibits JAK kinases

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Structure and function of a new STAT-induced STAT inhibitor

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Twenty proteins containing a C-terminal SOCS box form five structural classes

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Specific inhibition of Stat3 signal transduction by PIAS3

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Inhibition of Stat1-mediated gene activation by PIAS1

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Negative regulation of the JAK/STAT pathway

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Negative regulators of cytokine signaling

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Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells

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CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling

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JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

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Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia

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CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.

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SV40-transformed simian cells support the replication of early SV40 mutants

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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

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Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

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Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes

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HTLV-I-associated myelopathy endemic in Texas-born residents and isolation of virus from CSF cells

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Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus

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Characterization of a HTLV-I-infected cell line derived from a patient with adult T-cell leukemia with stable co-expression of CD4 and CD8.

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Jaks and STATs: biological implications

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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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Protein-tyrosine kinase-dependent activation of STAT transcription factors in interleukin-2- or interleukin-4-stimulated T lymphocytes

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Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton

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10.1016/S0145-2126(03)00158-9

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