(Q28187818)

English

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

scientific article (publication date: 26 September 2003)

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scholarly article

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A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha (English)

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protein ubiquitination

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based on heuristic

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author name string

Eric D Tang

1

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Cun-Yu Wang

2

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Yue Xiong

3

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Kun-Liang Guan

4

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language of work or name

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publication date

26 September 2003

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Journal of Biological Chemistry

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278

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37297-305

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39

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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NF-kappa B: ten years after

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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NF-kappaB signaling pathways in mammalian and insect innate immunity

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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The IKK complex: an integrator of all signals that activate NF-kappaB?

1 reference

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21 January 2018

Structure, regulation and function of NF-kappa B

1 reference

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21 January 2018

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

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Identification and characterization of an IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

1 reference

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21 January 2018

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

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21 January 2018

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

1 reference

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21 January 2018

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

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X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

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https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation

1 reference

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21 January 2018

A system for stable expression of short interfering RNAs in mammalian cells

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

1 reference

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

1 reference

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

1 reference

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21 January 2018

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1 reference

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TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

1 reference

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Regulation of TRAF2 signaling by self-induced degradation.

1 reference

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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Mechanisms underlying ubiquitination

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Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein

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21 January 2018

Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK.

1 reference

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21 January 2018

Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2).

1 reference

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

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21 January 2018

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

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21 January 2018

The essential role of MEKK3 in TNF-induced NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303389200

21 January 2018

The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

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Identifiers

10.1074/JBC.M303389200

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