(Q28191619)

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5-lipoxygenase and FLAP

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5-lipoxygenase and FLAP (English)

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M Peters-Golden

1

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T G Brock

2

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language of work or name

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publication date

2003

1 reference

Prostaglandins, Leukotrienes and Essential Fatty Acids

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69

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2-3

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99-109

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On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors

1 reference

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Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase

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Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions

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Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences

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Physiochemical characterization of ATP binding to human 5-lipoxygenase.

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7 January 2021

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Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils.

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Regulation of eicosanoid biosynthesis in the macrophage. Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors.

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Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells.

1 reference

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7 January 2021

based on heuristic

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Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase

1 reference

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7 January 2021

based on heuristic

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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

1 reference

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7 January 2021

based on heuristic

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Endogenous nitric oxide inhibits leukotriene B4 release from rat alveolar macrophages

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7 January 2021

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Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis

1 reference

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7 January 2021

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The three-dimensional structure of an arachidonic acid 15-lipoxygenase

1 reference

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7 January 2021

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Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

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7 January 2021

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Structural and thermochemical characterization of lipoxygenase-catechol complexes

1 reference

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7 January 2021

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The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

1 reference

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7 January 2021

based on heuristic

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Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Microsomal metabolism of the 5-lipoxygenase inhibitor L-739,010: evidence for furan bioactivation

1 reference

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7 January 2021

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inferred from DOI database lookup

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and isolation of a membrane protein necessary for leukotriene production

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5-lipoxygenase-activating protein is an arachidonate binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY X1005 and other quinoline derivatives in intact cells and a cell-free system--implications for the function of 5-lipoxygenase activating protein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane localization and topology of leukotriene C4 synthase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Complexes of sequential metabolic enzymes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

cDNA Cloning, Expression, Mutagenesis, Intracellular Localization, and Gene Chromosomal Assignment of Mouse 5-Lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The PPARalpha-leukotriene B4 pathway to inflammation control.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Covalent binding of LTA(4) to nucleosides and nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of 5-lipoxygenase with cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor beta upregulates 5-lipoxygenase activity during myeloid cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

c-kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5-Lipoxygenase upregulation by dexamethasone in human mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucocorticoid receptors are required for up-regulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the human 5-lipoxygenase gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and functional analysis of the mouse 5-lipoxygenase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0952-3278%2803%2900070-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0952-3278(03)00070-X

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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