(Q28200200)

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Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

scientific article (publication date: June 2001)

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scholarly article

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Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis (English)

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atherosclerosis

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author name string

C Song

1

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R A Hiipakka

2

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S Liao

3

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language of work or name

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publication date

June 2001

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66

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6

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473-9

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Low density lipoprotein oxidation and its pathobiological significance

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Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

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PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

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Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

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The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

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Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

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High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

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Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

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10.1016/S0039-128X(00)00239-7

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