(Q28202234)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

title

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

Bruton agammaglobulinemia tyrosine kinase

13 November 2019

main subject

1 reference

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Giuseppe Bardi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Alexander Gray

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Martin Turner

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

author name string

Elizabeth Clayton

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Sarah E Bell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

David Chantry

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

C Peter Downes

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Lisa A Humphries

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

David Rawlings

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Helen Reynolds

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Elena Vigorito

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

language of work or name

English

0 references

publication date

1 September 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

13 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

volume

196

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

page(s)

753-763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

cites work

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20 March 2017

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Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase

20 March 2017

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20 March 2017

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p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

20 March 2017

1 reference

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p110δ, a novel phosphoinositide 3-kinase in leukocytes

20 March 2017

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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

20 March 2017

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Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2

20 March 2017

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Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling

20 March 2017

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Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

20 March 2017

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Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling

20 March 2017

1 reference

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Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

20 March 2017

1 reference

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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

20 March 2017

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A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice

20 March 2017

1 reference

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Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

20 March 2017

1 reference

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Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

20 March 2017

1 reference

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Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes

20 March 2017

1 reference

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Cellular survival: a play in three Akts

20 March 2017

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Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

7 April 2017

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

7 April 2017

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7 April 2017

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Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.

29 September 2017

1 reference

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BLNK mediates Syk-dependent Btk activation

29 September 2017

1 reference

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Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene.

29 September 2017

1 reference

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Antibody regulation of B cell development

29 September 2017

1 reference

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Cd19-dependent activation of Akt kinase in B-lymphocytes

29 September 2017

1 reference

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Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)

29 September 2017

1 reference

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29 September 2017

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Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases

29 September 2017

1 reference

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The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphos

29 September 2017

1 reference

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Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

29 September 2017

1 reference

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Signal transduction pathways that regulate the fate of B lymphocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

SHIP modulates immune receptor responses by regulating membrane association of Btk.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Essential immunoregulatory role for BCAP in B cell development and function

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194055

Vav and the B cell signalosome

27 November 2018

1 reference

12 December 2020

CD1high B cells: a population of mixed origin

1 reference

12 December 2020

CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches

1 reference

12 December 2020

A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals

1 reference

12 December 2020

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

1 reference

12 December 2020

Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

1 reference

12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20020805

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12235209%20AND%20SRC:MED&resulttype=core&format=json