(Q28205804)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Michael Tymianski

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

0 references

publication date

1 September 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

published in

Biochemical Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

66

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

877-886

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

7 November 2019

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7 January 2021

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7 January 2021

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7 January 2021

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Synaptic activity mediates death of hypoxic neurons

7 January 2021

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The metabotropic glutamate receptors: structure and functions

7 January 2021

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7 January 2021

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Reduction of Potassium Conductances Mediated by Metabotropic Glutamate Receptors in Rat CA3 Pyramidal Cells Does Not Require Protein Kinase C or Protein Kinase A.

7 January 2021

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Glutamate metabotropic receptors increase a Ca(2+)-activated nonspecific cationic current in CA1 hippocampal neurons

7 January 2021

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Activation of mGluR5 modulates GABA(A) receptor function in retinal amacrine cells

7 January 2021

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The structure and function of glutamate receptor ion channels

7 January 2021

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NMDA receptor subunits: diversity, development and disease

7 January 2021

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Mammalian ionotropic glutamate receptors.

7 January 2021

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Plasticity: downstream of glutamate

7 January 2021

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Postsynaptic signaling and plasticity mechanisms

7 January 2021

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Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

7 January 2021

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Cloned glutamate receptors

7 January 2021

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Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition

7 January 2021

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Identification of a site in glutamate receptor subunits that controls calcium permeability

7 January 2021

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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

7 January 2021

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Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil

7 January 2021

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The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

7 January 2021

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White matter injury in spinal cord ischemia: protection by AMPA/kainate glutamate receptor antagonism

7 January 2021

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Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Structure and function of the NMDA receptor channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Molecular cloning and characterization of the rat NMDA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Assessment of mitochondrial membrane potential as an indicator of cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Ionic dependence of glutamate neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Glutamate neurotoxicity in cortical cell culture.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Glutamate neurotoxicity in cortical cell culture is calcium dependent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Glutamate neurotoxicity, calcium, and zinc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Hypoxic neurodegeneration in culture: calcium influx, electron microscopy, and neuroprotection with excitatory amino acid antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Calcium signaling in neurons: molecular mechanisms and cellular consequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

The postsynaptic density at glutamatergic synapses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Differences in membrane structure between excitatory and inhibitory synapses in the cerebellar cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

7 January 2021

The postsynaptic density

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

N-cadherin is a major glycoprotein component of isolated rat forebrain postsynaptic densities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Signal transduction molecules at the glutamatergic postsynaptic membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Binding of neuroligins to PSD-95

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Regulated subcellular distribution of the NR1 subunit of the NMDA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Regulation of signal transduction by protein targeting: the case for CaMKII.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

NMDA channel regulation by channel-associated protein tyrosine kinase Src.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Competitive binding of alpha-actinin and calmodulin to the NMDA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

NSF binding to GluR2 regulates synaptic transmission

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

An intramolecular interaction between Src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Laminar organization of the NMDA receptor complex within the postsynaptic density.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Molecular organization of the postsynaptic specialization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

PDZ domains: structural modules for protein complex assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Interaction of ion channels and receptors with PDZ domain proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Synapse structure: glutamate receptors connected by the shanks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Identification of ion channel-associated proteins using the yeast two-hybrid system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

AMPA receptor trafficking and synaptic plasticity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Nitric oxide signaling in the nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

AMPA receptor antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Inhibitors of AMPA and kainate receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Cellular uptake of the tat protein from human immunodeficiency virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

TAT-mediated protein transduction into mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Plasma clearance, tissue distribution and catabolism of cationized albumins with increasing isoelectric points in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Cell-penetrating peptides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Messenger proteins: homeoproteins, TAT and others

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Intercellular trafficking and protein delivery by a herpesvirus structural protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

In vivo protein transduction: delivery of a biologically active protein into the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Protein modules and signalling networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

Small molecule antagonists of proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900297-1

10.1016/S0006-2952(03)00297-1

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12963474%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference