(Q28213774)

English

Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes

scientific article (publication date: 29 March 2001)

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scholarly article

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Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes (English)

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author name string

W Ma

1

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C Xia

2

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P Ling

3

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M Qiu

4

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Y Luo

5

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T H Tan

6

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M Liu

7

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language of work or name

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publication date

29 March 2001

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20

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1703-14

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14

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SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1

1 reference

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21 January 2018

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

1 reference

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21 January 2018

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

1 reference

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21 January 2018

Regulatory and signaling properties of the Vav family

1 reference

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21 January 2018

Regulation of antigen receptor signal transduction by protein tyrosine kinases

1 reference

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21 January 2018

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

1 reference

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21 January 2018

Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene

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21 January 2018

Integration of T cell receptor-dependent signaling pathways by adapter proteins

1 reference

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21 January 2018

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

1 reference

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21 January 2018

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1 reference

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21 January 2018

Signal transmission between the plasma membrane and nucleus of T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1 reference

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21 January 2018

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation

1 reference

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21 January 2018

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

1 reference

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21 January 2018

GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28

1 reference

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21 January 2018

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

1 reference

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21 January 2018

BLNK: a central linker protein in B cell activation

1 reference

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21 January 2018

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade

1 reference

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21 January 2018

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

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21 January 2018

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

1 reference

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21 January 2018

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1 reference

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21 January 2018

GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation

1 reference

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21 January 2018

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase

1 reference

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21 January 2018

HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1 reference

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21 January 2018

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

1 reference

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21 January 2018

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.

1 reference

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21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

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21 January 2018

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Requirement for B cell linker protein (BLNK) in B cell development

1 reference

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21 January 2018

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line

1 reference

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21 January 2018

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

1 reference

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21 January 2018

Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

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21 January 2018

Adaptors and molecular scaffolds in immune cell signaling

1 reference

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21 January 2018

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

1 reference

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21 January 2018

JNK is involved in signal integration during costimulation of T lymphocytes.

1 reference

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21 January 2018

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling

1 reference

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21 January 2018

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes

1 reference

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21 January 2018

Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction

2 references

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Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

1 reference

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21 January 2018

Complex complexes: signaling at the TCR.

1 reference

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21 January 2018

Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1 reference

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21 January 2018

Signal transduction by lymphocyte antigen receptors

1 reference

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21 January 2018

A mammalian scaffold complex that selectively mediates MAP kinase activation

1 reference

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GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity

1 reference

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21 January 2018

The role of membrane-associated adaptors in T cell receptor signalling

1 reference

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21 January 2018

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204224

21 January 2018

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

1 reference

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21 January 2018

Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade

1 reference

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Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

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Monitoringhprt mutant frequency over time in T-lymphocytes of people accidentally exposed to high doses of ionizing radiation

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Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1 reference

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Minimum length of sequence homology required for in vivo cloning by homologous recombination in yeast

1 reference

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based on heuristic

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation and function of the JNK subgroup of MAP kinases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1

1 reference

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based on heuristic

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1204224

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10.1038/sj.onc.1204224

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