(Q28214238)

English

The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status

scientific article (publication date: 21 June 2002)

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scholarly article

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The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status (English)

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phosphorylation

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1 reference

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author name string

Megumi Adachi

1

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Elaine J Lewis

2

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language of work or name

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publication date

21 June 2002

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Journal of Biological Chemistry

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277

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25

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22915-24

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Transcriptional control of neurotransmitter phenotype

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The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

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Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2

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The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes

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Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription

1 reference

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The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein

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Regulation of transcription factor function by phosphorylation.

1 reference

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The regulation of transcription by phosphorylation

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Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

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Cellular and molecular determinants of sympathetic neuron development

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The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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Receptor tyrosine phosphatases in axon growth and guidance

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Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'.

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

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Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

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Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells

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Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins.

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Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis

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AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene

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DNA binding by cut homeodomain proteins is down-modulated by casein kinase II

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Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

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Identifiers

10.1074/JBC.M201695200

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