(Q28214558)

English

Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells

scientific article (publication date: 8 March 2002)

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scholarly article

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Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells (English)

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author name string

Mika Suzuki

1

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Hiroshi Kobayashi

2

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Michio Fujie

3

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Takashi Nishida

4

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Masaharu Takigawa

5

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Naohiro Kanayama

6

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Toshihiko Terao

7

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language of work or name

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publication date

8 March 2002

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Journal of Biological Chemistry

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277

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10

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8022-32

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Inter-α-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily

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Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells

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Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent

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Inter-alpha-trypsin inhibitor bound to tumor cells is cleaved into the heavy chains and the light chain on the cell surface

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A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis

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Identity of urinary trypsin inhibitor-binding protein to link protein

1 reference

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Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration

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Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways

1 reference

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CD44 is the principal cell surface receptor for hyaluronate

1 reference

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Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells

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Tumor invasion: a consequence of destructive and compositional matrix alterations

1 reference

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CD44--a molecule involved in leukocyte adherence and T-cell activation

1 reference

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A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody

1 reference

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Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes

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Alternating laminated array of two types of mucin in the human gastric surface mucous layer

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Glucocorticoid-modulated gene expression of tissue- and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2

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Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity

1 reference

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Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.

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Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasion

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Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro

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Inhibition of metastasis of lewis lung carcinoma by urinary trypsin inhibitor in experimental and spontaneous metastasis models

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Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitor

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Human myometrial cells in culture express specific binding sites for urinary trypsin inhibitor

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Suppression of urokinase-type plasminogen activator expression from human ovarian cancer cells by urinary trypsin inhibitor

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Stimulation of glycosaminoglycan production in murine tumors

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Identifiers

10.1074/JBC.M108545200

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