(Q28218204)

English

Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders

scientific article (publication date: September 2002)

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scholarly article

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Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders (English)

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author name string

X Wu

1

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T Daniels

2

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C Molinaro

3

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M B Lilly

4

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C A Casiano

5

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language of work or name

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publication date

September 2002

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Cell Death & Differentiation

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9

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9

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915-25

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Atopic dermatitis: new insights and opportunities for therapeutic intervention

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Atopic dermatitis: is it an allergic disease?

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Immune regulation in atopic dermatitis

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Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions

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Autoantibodies in atopic dermatitis

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Anti-elongation factor-1alpha autoantibody in adult atopic dermatitis patients

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Characterization of IgE-reactive autoantigens in atopic dermatitis. 1. Subcellular distribution and tissue-specific expression

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Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

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Humoral immune response directed against LEDGF in patients with VKH.

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Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

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Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress

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Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina

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Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

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Activation of LEDGF gene by thermal-and oxidative-stresses

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Role of apoptosis in atopic dermatitis

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Cytokine network and dysregulated apoptosis in atopic dermatitis

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T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

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Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis

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Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes

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Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for systemic autoimmunity

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DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

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Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

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Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

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Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens

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Remnants of suicidal cells fostering systemic autoaggression. Apoptosis in the origin and maintenance of autoimmunity

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

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Proteases for cell suicide: functions and regulation of caspases

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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Caspases: the executioners of apoptosis

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Caspase-3 mediated cleavage of HsRad51 at an unconventional site.

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Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

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The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

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Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing

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Conversion of Bcl-2 to a Bax-like death effector by caspases

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Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

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Molecular biology of HMGA proteins: hubs of nuclear function

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Corpse clearance defines the meaning of cell death

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Necrotic death pathway in Fas receptor signaling

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Gone but not forgotten

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Autoallergy: a pathogenetic factor in atopic dermatitis?

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Characterization of IgE-reactive autoantigens in atopic dermatitis. 2. A pilot study on IgE versus IgG subclass response and seasonal variation of IgE autoreactivity

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LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes

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Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

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10.1038/SJ.CDD.4401063

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