(Q28242282)

1

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Cédric Lamy

2

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Neil V Marrion

3

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Jean-François Liégeois

4

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Vincent Seutin

5

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language of work or name

English

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publication date

16 August 2011

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published in

ChemBioChem

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volume

12

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issue

12

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page(s)

1808-12

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cites work

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Ion channel pharmacology.

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How many drug targets are there?

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Animal peptides targeting voltage-activated sodium channels.

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Voltage-gated ion channels and gating modifier toxins.

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Electrostatic tuning of cellular excitability

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Determinants of apamin and d-tubocurarine block in SK potassium channels

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Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents.

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The SK3 Subunit of Small Conductance Ca2+-activated K+ Channels Interacts with Both SK1 and SK2 Subunits in a Heterologous Expression System

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An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels

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Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels

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Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation

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Mutations stabilizing an open conformation within the external region of the permeation pathway of the potassium channel KcsA.

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The aromatic binding site for tetraethylammonium ion on potassium channels

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Tetraethylammonium binding to the outer mouth of the KcsA potassium channel: implications for ion permeation

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Mechanisms of tetraethylammonium ion block in the KcsA potassium channel

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Extracellular blockade of potassium channels by TEA+: the tip of the iceberg?

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Structural basis of TEA blockade in a model potassium channel

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Charybdotoxin selectively blocks small Ca-activated K channels in Aplysia neurons

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Subset-specific expression of potassium channels in developing murine T lymphocytes

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Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features

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Competition for block of a Ca2(+)-activated K+ channel by charybdotoxin and tetraethylammonium

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Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel

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Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.

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The alpha-dendrotoxin footprint on a mammalian potassium channel.

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Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

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Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

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Allosteric block of KCa2 channels by apamin

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Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers

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Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices

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Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels

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Characterisation of [(125)I]-apamin binding sites in rat brain membranes with HE293 cells transfected with SK channel subtypes

21 January 2018

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Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel

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Blockade by dendrotoxin homologues of voltage-dependent K+ currents in cultured sensory neurones from neonatal rats

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The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells

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A snake toxin inhibitor of inward rectifier potassium channel ROMK1.

21 January 2018

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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain

21 January 2018

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Pore region of TRPV3 ion channel is specifically required for heat activation

21 January 2018

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A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating

21 January 2018

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Identification of a pharmacophore of SKCa channel blockers

21 January 2018

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Nuclear magnetic resonance solution structure of dendrotoxin K from the venom of Dendroaspis polylepis polylepis

21 January 2018

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Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins

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