(Q28244790)

English

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity

scientific article (publication date: 22 September 2011)

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Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity (English)

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author name string

M V Ramana Reddy

1

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Padmavathi Venkatapuram

2

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Muralidhar R Mallireddigari

3

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Venkat R Pallela

4

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Stephen C Cosenza

5

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Kimberly A Robell

6

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Balaiah Akula

7

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Benjamin S Hoffman

8

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E Premkumar Reddy

9

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language of work or name

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publication date

22 September 2011

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Journal of Medicinal Chemistry

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54

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18

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6254-76

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

1 reference

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The National Cancer Institute: cancer drug discovery and development program

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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10.1021/JM200570P

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