(Q28246649)

1

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S V Otton

2

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T Inaba

3

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W Kalow

4

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E M Sellers

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

5

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language of work or name

English

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publication date

1 June 1997

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published in

Biochemical Pharmacology

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volume

53

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issue

11

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page(s)

1605-12

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900014-2

7 January 2021

Metabolic polymorphisms

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Clinical significance of the sparteine/debrisoquine oxidation polymorphism

7 January 2021

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"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

7 January 2021

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Molecular genetics of the debrisoquin-sparteine polymorphism

7 January 2021

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Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

7 January 2021

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Dextromethorphan: enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6.

7 January 2021

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Inhibition by fluoxetine of cytochrome P450 2D6 activity.

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The metabolic fate of amphetamine in man and other species

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Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

7 January 2021

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The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

7 January 2021

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Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl] propane [(methylenedioxy)methamphetamine]

7 January 2021

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Stereoselective accumulation of hydroxylated metabolites of amphetamine in rat striatum and hypothalamus

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Determination of amphetamine, norephedrine, and their phenolic metabolites in rat brain by gas chromatography.

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Formation of &alpha;-Methyldopamine (&lsquo;Catecholamphetamine&rsquo;) from p-Hydroxyamphetamine by Rat Brain Microsomes

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MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

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Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

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Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

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Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver

7 January 2021

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Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives

7 January 2021

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Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

7 January 2021

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Spectral and inhibitory interactions of (+/-)-3,4-methylenedioxyamphetamine (MDA) and (+/-)-3,4-methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes

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Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

7 January 2021

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