(Q28249524)

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Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

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Europe PubMed Central

Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen (English)

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Peter L Pedersen

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publication date

June 2007

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Journal of Bioenergetics and Biomembranes

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39

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3

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211-22

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Colorectal cancer epigenetics: the role of environmental factors and the search for molecular biomarkers

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Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography

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Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box

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21 January 2018

Altered metabolic states do not change the intracellular distribution of hexokinase in Zajdela hepatoma ascites cells

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21 January 2018

Mitochondrial hexokinases: guardians of the mitochondria

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21 January 2018

On the role of VDAC in apoptosis: fact and fiction

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12 December 2020

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On respiratory impairment in cancer cells

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12 December 2020

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Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

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12 December 2020

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Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

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12 December 2020

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Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding

1 reference

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12 December 2020

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Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC

1 reference

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12 December 2020

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Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.

1 reference

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12 December 2020

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Pyruvate transport in tumour-cell mitochondria

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12 December 2020

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

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12 December 2020

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Establishment of a transplantable ascites variant of a rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene

1 reference

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12 December 2020

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Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase

1 reference

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12 December 2020

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Oxidative metabolism in cancer growth

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial hexokinase. Release, rebinding, and location

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https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolytic regulation in rat liver and hepatomas.

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https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

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Glucose phosphorylation. Site-directed mutations which impair the catalytic function of hexokinase

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https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pore protein and the hexokinase-binding protein from the outer membrane of rat liver mitochondria are identical

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the development, biochemistry, and biology of experimental hepatomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondria as therapeutic targets for cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

1 reference

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12 December 2020

based on heuristic

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The molecular correlation concept of neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer's molecular sweet tooth and the Warburg effect.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

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Tumor Mitochondria and the Bioenergetics of Cancer Cells

1 reference

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12 December 2020

based on heuristic

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Biochemical and ultrastructural properties of a mitochondrial inner membrane fraction deficient in outer membrane and matrix activities

1 reference

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12 December 2020

based on heuristic

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Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A candidate for the permeability pathway of the outer mitochondrial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

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Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

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Mitochondria and human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of some ultrastructural and biochemical properties of mitochondria from Morris hepatomas 9618A, 7800, and 3924A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

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inferred from PubMed ID database lookup

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

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inferred from PubMed ID database lookup

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alkylation of isocitrate lyase from Escherichia coli by 3-bromopyruvate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

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Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the InterAktion between hexokinase and the mitochondrion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic and spectral analysis of cytochrome oxidase in adult and fetal rat liver and Morris hepatoma 3924A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cancer cell's "power plants" as promising therapeutic targets: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor metabolism: new opportunities for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial ATP synthase. Crystal structure of the catalytic F1 unit in a vanadate-induced transition-like state and implications for mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a complex between yeast hexokinase A and glucose. I. Structure determination and refinement at 3.5 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positron emission tomography provides molecular imaging of biological processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the significance of glucolysis for cancer growth, with special reference to Morris rat hepatomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexokinase II: the integration of energy metabolism and control of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The voltage-dependent anion channel-1 modulates apoptotic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic properties of the inner and outer membranes of rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondria and cancer: Warburg addressed

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of efficient chemoembolization mixtures by magnetic resonance imaging therapy monitoring: an experimental study on the VX2 tumor in the rabbit liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17879147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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