(Q28250437)

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Opioid metabolism

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scholarly article

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Europe PubMed Central

Opioid metabolism (English)

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author name string

Howard S Smith

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publication date

July 2009

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84

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613-24

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Codeine intoxication associated with ultrarapid CYP2D6 metabolism

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20 March 2017

Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action

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20 March 2017

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

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20 March 2017

Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro

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20 March 2017

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

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20 March 2017

Morphine intoxication in renal failure: the role of morphine-6-glucuronide

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20 March 2017

Chronic nausea and morphine-6-glucuronide

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20 March 2017

Forensic drug testing for opiates, III. Urinary excretion rates of morphine and codeine following codeine administration

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20 March 2017

Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro

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20 March 2017

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

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20 March 2017

Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

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29 September 2017

Interindividual variability of methadone response: impact of genetic polymorphism

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29 September 2017

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

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29 September 2017

Rational use and interpretation of urine drug testing in chronic opioid therapy.

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29 September 2017

Complicated pain management in a CYP450 2D6 poor metabolizer

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29 September 2017

The use of opioid analgesia in end-stage renal disease patients managed without dialysis: recommendations for practice.

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29 September 2017

Enantiomeric metabolic interactions and stereoselective human methadone metabolism

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29 September 2017

A case of serotonin syndrome and mutism associated with methadone

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29 September 2017

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites

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29 September 2017

Opioid switching: a systematic and critical review

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29 September 2017

Pharmacology of methadone and its isomers.

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29 September 2017

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Opioids in renal failure and dialysis patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

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29 September 2017

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

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29 September 2017

Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related pain

1 reference

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29 September 2017

Unwanted effects of morphine-6-glucoronide and morphine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Opioid rotation in the treatment of joint pain. A review of 67 cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

The management of persistent pain in older persons

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Randomized placebo-controlled trial of the activity of the morphine glucuronides

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Opioid substitution to improve the effectiveness of chronic noncancer pain control: a chart review

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29 September 2017

Opioid rotation for cancer pain: rationale and clinical aspects

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Epidemiological features of chronic low-back pain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Morphine poisoning in chronic kidney failure. Morphine-6-glucuronide as a pharmacologically active morphine metabolite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

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29 September 2017

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Effects of aging on the renal glomerulus

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29 September 2017

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations

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29 September 2017

Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

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29 September 2017

The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive‐care patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

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29 September 2017

Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

29 September 2017

Evidence that morphine is metabolized to hydromorphone but not to oxymorphone

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Fentanyl pharmacokinetics in patients undergoing renal transplantation.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

A Study of Codeine Metabolism

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Morphine pharmacokinetics in renal failure.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Influence of renal function on the elimination of morphine and morphine glucuronides.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Studies on morphine disposition: influence of renal failure on the kinetics of morphine and its metabolites

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

2 June 2018

Longitudinal studies on the rate of decline in renal function with age.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

20 June 2018

Myoclonus associated with high-dose parenteral methadone

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Regarding CYP450 2D6 poor metabolizers

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

The detection of hydromorphone in urine specimens with high morphine concentrations

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

CYP2D6 ultrarapid metabolism and morphine/codeine ratios in blood: was it codeine or heroin?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4.

1 reference

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27 November 2018

Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Methadone-induced myoclonus in advanced cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Identification of hydrocodone in human urine following controlled codeine administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone.

1 reference

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27 November 2018

Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Fentanyl pharmacokinetics in anaesthetized patients with cirrhosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704133

27 November 2018

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

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https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Hepatocyte Nuclear Factor-1alpha Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Gas chromatographic study of the urinary codeine-to-morphine ratios in controlled codeine consumption and in mass screening for opiate drugs

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https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Simultaneous determination of codeine and morphine in urine and blood by HPLC

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

A pilot study to determine the usefulness of the urinary excretion of methadone and its primary metabolite (EDDP) as potential markers of compliance in methadone detoxification programs

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https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Hepatic extraction of morphine is impaired in cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Methadone disposition in patients with chronic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Hydromorphone metabolite accumulation in renal failure

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Methadone is poorly removed by haemodialysis

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Methadone use in patients with chronic renal disease

1 reference

https://api.crossref.org/works/10.1016%2FS0025-6196%2811%2960750-7

7 January 2021

Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19567715

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S0025-6196(11)60750-7

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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