(Q28251494)

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Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

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Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells (English)

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apoptotic process

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1 reference

based on heuristic

inferred from title

author name string

Guanghu Wang

1

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Jeane Silva

2

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Kannan Krishnamurthy

3

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Eric Tran

4

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Brian G Condie

5

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Erhard Bieberich

6

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language of work or name

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publication date

15 July 2005

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Journal of Biological Chemistry

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280

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26415-24

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28

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Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

CERT mediates intermembrane transfer of various molecular species of ceramides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Interaction of earthworm hemolysin with lipid membranes requires sphingolipids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Differential interaction of Sophora isoflavonoids with lipid bilayers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Aggregation and fusion of vesicles composed of N-palmitoyl derivatives of membrane phospholipids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Intracellular signal transduction pathways activated by ceramide and its metabolites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide enables fas to cap and kill.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

CD95 rapidly clusters in cells of diverse origins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide and cell death receptor clustering

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Mouse anti-ceramide antiserum: a specific tool for the detection of endogenous ceramide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Regulation of mature T lymphocyte proliferation and differentiation by Par-4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide: second messenger or modulator of membrane structure and dynamics?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

CD95 Signaling via Ceramide-rich Membrane Rafts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Ceramide-mediated clustering is required for CD95-DISC formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501492200

21 January 2018

Identifiers

10.1074/JBC.M501492200

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