(Q28252165)

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The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling (English)

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1-(1Z)-hexadecenyl-2-arachidonoyl-sn-glycero-3-phosphocholine

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ChEBI release 2020-05-28

phospholipase A2 group VI

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GOA release 2020-03-11

Patatin like phospholipase domain containing 8

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GOA release 2020-03-11

calcium-independent phospholipase A2 activity

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GOA release 2020-03-11

author name string

Wei Yan

1

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Christopher M Jenkins

2

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Xianlin Han

3

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David J Mancuso

4

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Harold F Sims

5

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Kui Yang

6

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Richard W Gross

7

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language of work or name

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publication date

22 July 2005

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Journal of Biological Chemistry

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280

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26669-79

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29

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

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21 January 2018

The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)

1 reference

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21 January 2018

A novel intracellular membrane-bound calcium-independent phospholipase A(2)

1 reference

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21 January 2018

Identification of hepatic peroxisomal phospholipase A(2) and characterization of arachidonic acid-containing choline glycerophospholipids in hepatic peroxisomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

1 reference

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21 January 2018

Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cell

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Regulatory mechanism and physiological role of cytosolic phospholipase A2

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21 January 2018

Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2.

1 reference

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21 January 2018

Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization

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21 January 2018

Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways

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21 January 2018

A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells

1 reference

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21 January 2018

Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells

1 reference

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21 January 2018

Diglyceride lipase: a pathway for arachidonate release from human platelets

1 reference

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21 January 2018

Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation

1 reference

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21 January 2018

Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Purification of a lysophospholipase from bovine brain that selectively deacylates arachidonoyl-substituted lysophosphatidylcholine.

1 reference

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21 January 2018

Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

A second endogenous cannabinoid that modulates long-term potentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Enzymatic properties of human cytosolic phospholipase A(2)gamma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Separation of isomeric lysophospholipids by reverse phase HPLC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2.

1 reference

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21 January 2018

Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammali

1 reference

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21 January 2018

Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1

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https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2

1 reference

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21 January 2018

Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2

1 reference

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21 January 2018

Purification of Recombinant Human cPLA2γ and Identification of C-Terminal Farnesylation, Proteolytic Processing, and Carboxymethylation by MALDI-TOF-TOF Analysis

1 reference

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21 January 2018

Purification and regiospecificity of multiple enzyme activities of phospholipase A(1) from bonito muscle

1 reference

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21 January 2018

Structure and function of phosphatidylserine-specific phospholipase A1

1 reference

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21 January 2018

Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta

1 reference

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21 January 2018

A novel mechanism for the store-operated calcium influx pathway

1 reference

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21 January 2018

The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

RETRACTED: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

T cell chemotaxis to lysophosphatidylcholine through the G2A receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502358200

21 January 2018

Toward understanding interfacial activation of secretory phospholipase A2 (PLA2): membrane surface properties and membrane-induced structural changes in the enzyme contribute synergistically to PLA2 activation

1 reference

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21 January 2018

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10.1074/JBC.M502358200

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