(Q28256068)

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Bcl-2 associates with the ras-related protein R-ras p23

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Bcl-2 associates with the ras-related protein R-ras p23 (English)

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author name string

M J Fernandez-Sarabia

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J R Bischoff

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publication date

18 November 1993

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366

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6452

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274-5

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Apoptosis and signal transduction: clues to a molecular mechanism

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Toward an understanding of the molecular mechanisms of physiological cell death.

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

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bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

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Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells

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Apoptotic cell death induced by c-myc is inhibited by bcl-2.

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

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Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

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Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice

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Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

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Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2

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The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest

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Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

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Heterologous expression and characterization of the human R-ras gene product

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Chimeric proteins define variable and essential regions of Ha-ras-encoded protein

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The bcl-2 gene encodes a novel G protein

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Small G proteins are expressed ubiquitously in lymphoid cells and do not correspond to Bcl-2.

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The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

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10.1038/366274A0

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