(Q28256613)

2

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Christopher F Mojcik

3

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Robert A Brodsky

4

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Leonard Bell

Complement-specific antibodies: designing novel anti-inflammatories

5

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language of work or name

English

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publication date

November 2007

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published in

Nature Biotechnology

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volume

25

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page(s)

1256-64

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issue

11

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cites work

1 reference

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Complement. Second of two parts

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The structure of complement C3b provides insights into complement activation and regulation.

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7 January 2021

Structures of complement component C3 provide insights into the function and evolution of immunity

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Structure of C3b reveals conformational changes that underlie complement activity

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Structure of C3b in complex with CRIg gives insights into regulation of complement activation

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Indications for the immunological evaluation of patients with meningitis

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Generation of C5a in the absence of C3: a new complement activation pathway

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Molecular organization and function of the complement system

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The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview

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C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

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Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria

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Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene

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Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine

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Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.

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Reshaping human antibodies for therapy

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Expressed human immunoglobulin kappa genes and their hypermutation

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Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells

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The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region

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Human antibody effector function

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Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation

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Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

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Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease

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Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.

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Inhibition of terminal complement: a novel therapeutic approach for the treatment of systemic lupus erythematosus

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Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial.

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Pexelizumab and the APEX AMI trial

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Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes

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Diagnosis and management of paroxysmal nocturnal hemoglobinuria

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Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

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PIG-A mutations in normal hematopoiesis

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7 January 2021

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals

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7 January 2021

The PNH phenotype cells that emerge in most patients after CAMPATH-1H therapy are present prior to treatment.

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7 January 2021

Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.

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7 January 2021

Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor

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7 January 2021

Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria

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7 January 2021

Enhanced reactive lysis of paroxysmal nocturnal hemoglobinuria erythrocytes. Studies on C9 binding and incorporation into high molecular weight complexes

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Fatigue in cancer patients compared with fatigue in the general United States population.

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Quality of life may be affected more by disease parameters and response to therapy than by haemoglobin changes.

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The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

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Activated platelets in paroxysmal nocturnal haemoglobinuria

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Cerebral ischemic infarction in paroxysmal nocturnal hemoglobinuria report of 2 cases and updated review of 7 previously published patients

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7 January 2021

Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH).

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7 January 2021

Enhancement of platelet deposition by cross-linked hemoglobin in a rat carotid endarterectomy model

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7 January 2021

Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium

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The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

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Inhibition of clotting factor XIII activity by nitric oxide.

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7 January 2021

Reduced nitric oxide production by L-arginine deficiency in lysinuric protein intolerance exacerbates intravascular coagulation

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Natural history of paroxysmal nocturnal hemoglobinuria

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7 January 2021

Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology

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Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays

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High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria

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Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan.

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7 January 2021

Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype

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7 January 2021

Paroxysmal nocturnal haemoglobinuria with coexisting deficiency of the ninth component of complement: lack of massive haemolytic attack

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7 January 2021

Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria

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7 January 2021

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria

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7 January 2021

Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.

1 reference

7 January 2021

Prevention of acute vascular rejection by a functionally blocking anti-C5 monoclonal antibody combined with cyclosporine

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7 January 2021

The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice

1 reference

7 January 2021

In vitro demyelination by serum antibody from patients with guillain-barré syndrome requires terminal complement complexes

1 reference

7 January 2021

Basic and clinical aspects of autoimmune disorders in peripheral nerves

1 reference

7 January 2021

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

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7 January 2021

A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways.

1 reference

7 January 2021

Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange

1 reference

7 January 2021

Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response

1 reference

7 January 2021

Drusen complement components C3a and C5a promote choroidal neovascularization

1 reference

7 January 2021