(Q28264029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15168727%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

review article

1 reference

title

Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications (English)

1 reference

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29 December 2019

1

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29 December 2019

author name string

Francesca M Tumminello

2

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29 December 2019

Marilena Crescimanno

3

1 reference

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29 December 2019

Carla Flandina

4

1 reference

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29 December 2019

Nicola Gebbia

5

1 reference

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29 December 2019

language of work or name

English

0 references

publication date

1 January 2004

1 reference

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Clinical & Experimental Metastasis

29 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15168727%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

volume

21

1 reference

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29 December 2019

issue

2

1 reference

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29 December 2019

page(s)

91-106

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15168727%20AND%20SRC:MED&resulttype=core&format=json

Participation of the propeptide on procathepsin D activation of human peripheral lymphocytes and neutrophils

29 December 2019

cites work

1 reference

12 December 2020

The expression of proteolytic enzymes at the dermal invading front of primary cutaneous melanoma predicts metastasis

1 reference

12 December 2020

Acid protease secreted from human pancreatic carcinoma cell line HPC-YT into serum-free, chemically defined medium

1 reference

12 December 2020

Cathepsins D, B, and L in malignant human lung tissue

1 reference

12 December 2020

Expression of cathepsin D in transitional cell bladder tumours

1 reference

12 December 2020

Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma

1 reference

12 December 2020

Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors

1 reference

12 December 2020

Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer

1 reference

12 December 2020

Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival

1 reference

12 December 2020

Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder

1 reference

12 December 2020

Correlation of tumor markers p53, bcl-2 and cathepsin-D with clinicopathologic features and disease-free survival in laryngeal squamous cell carcinoma

1 reference

12 December 2020

Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study

1 reference

12 December 2020

Pepstatins: aspartic proteinase inhibitors having potential therapeutic applications

1 reference

12 December 2020

Inhibition of cathepsin D by tripeptides containing statine analogs

1 reference

12 December 2020

Analysis of the interaction of procathepsin D activation peptide with breast cancer cells

1 reference

12 December 2020

Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

1 reference

12 December 2020

Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices

1 reference

12 December 2020

Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status

1 reference

12 December 2020

Immunolocalization of cathepsin D in normal and neoplastic human tissues

1 reference

12 December 2020

The distribution of lysosomal cathepsin D in cardiac myocytes

1 reference

12 December 2020

Immunohistochemical localization of cathepsins D and E in human gastric cancer: a possible correlation with local invasive and metastatic activities of carcinoma cells

1 reference

12 December 2020

Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes

1 reference

12 December 2020

The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.

1 reference

12 December 2020

Activity of some lysosomal enzymes in serum and in tumors of patients with squamous cell lung carcinoma

1 reference

12 December 2020

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

1 reference

12 December 2020

Clinical relevance of biologic factors in male breast cancer

1 reference

12 December 2020

Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer

1 reference

12 December 2020

Cervical Lymph Node Status and Survival in Laryngeal Carcinoma: Prognostic Factors

1 reference

12 December 2020

The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry

1 reference

12 December 2020

Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues

1 reference

12 December 2020

The distribution of PSA, cathepsin‐D, and pS2 in BPH and cancer of the prostate

1 reference

12 December 2020

Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer

1 reference

12 December 2020

Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma

1 reference

12 December 2020

Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer

1 reference

12 December 2020

Cathepsin D in normal and neoplastic thyroid tissues

1 reference

12 December 2020

Acid-activated insulin-like growth factor binding protein protease activity of cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma

1 reference

12 December 2020

Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview

1 reference

12 December 2020

Cathepsin-D in Human Encjometrium: Induction by Progesterone and Potential Value as a Tumor Marker*

1 reference

12 December 2020

Mitogenic effects of certain cathepsins and calciferin on the intact liver in vivo

1 reference

12 December 2020

Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi

1 reference

12 December 2020

Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma

1 reference

12 December 2020

Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis

1 reference

12 December 2020

Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas

1 reference

12 December 2020

The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*

1 reference

12 December 2020

Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma

1 reference

12 December 2020

Role of procathepsin D activation peptide in prostate cancer growth

1 reference

12 December 2020

Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland

1 reference

12 December 2020

Activation of peripheral blood neutrophils and lymphocytes by human procathepsin D and insulin-like growth factor II.

1 reference

12 December 2020

Cathepsin D in the malignant progression of neoplastic diseases (review).

1 reference

12 December 2020

Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications

1 reference

12 December 2020

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

1 reference

12 December 2020

Cathepsin B and D expression in squamous cell carcinoma

1 reference

12 December 2020

Cathepsin D stimulates DNA synthesis and mitosis in mouse liver in vivo

1 reference

12 December 2020

Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer

1 reference

12 December 2020

Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.

1 reference

12 December 2020

Cathepsins D and E in normal, metaplastic, dysplastic, and carcinomatous gastric tissue: an immunohistochemical study

1 reference

12 December 2020

The fibrin(ogen)olytic properties of cathepsin D.

1 reference

12 December 2020

Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer

1 reference

12 December 2020

An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas

1 reference

12 December 2020

Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer

1 reference

12 December 2020

Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes

1 reference

12 December 2020

Role of cathepsin D in prostatic cancer cell growth and its regulation by brefeldin A

1 reference

12 December 2020

Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors

1 reference

12 December 2020

Immunoradiometric and immunohistochemical analysis of Cathepsin D in ovarian cancer: lack of association with clinical outcome

1 reference

12 December 2020

Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease.

1 reference

12 December 2020

Cathepsin D in cancer metastasis: a protease and a ligand

1 reference

12 December 2020

Cathepsin-D and tumor associated antigen DF3 in salivary gland neoplasia. Differential diagnostic and prognostic applications.

1 reference

12 December 2020

Cathepsin D Content in Colorectal Cancer

1 reference

12 December 2020

Proteases in cutaneous melanoma

1 reference

12 December 2020

Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma.

1 reference

12 December 2020

The clinical value of cathepsin-D and TNF-alpha in bladder cancer patients

1 reference

12 December 2020

May Cathepsin D Immunoreactivity Be Used as a Prognostic Factor in Endometrial Carcinomas? A Comparative Immunohistochemical Study

1 reference

12 December 2020

Cathepsin D expression in colorectal adenocarcinomas and adenomas

1 reference

12 December 2020

Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes

1 reference

12 December 2020

Molecular organization of the human cathepsin D gene

1 reference

12 December 2020

Proteolysis of glucagon within hepatic endosomes by membrane-associated cathepsins B and D

1 reference

12 December 2020

Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy

1 reference

12 December 2020

Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma

1 reference

12 December 2020

Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D

1 reference

12 December 2020

Progestin and estrogen control of cathepsin D expression and processing in rat uterine luminal epithelium and stroma-myometrium

1 reference

12 December 2020

Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells

1 reference

12 December 2020

Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms

1 reference

12 December 2020

The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations

1 reference

12 December 2020

Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.

1 reference

12 December 2020

Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters

1 reference

12 December 2020

Biochemical and immunohistochemical analysis of cathepsins B, H, L and D in human melanocytic tumours.

1 reference

12 December 2020

Clinical significance of cathepsin D in primary ovarian cancer

1 reference

12 December 2020

Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells

1 reference

12 December 2020

Distribution of the Mr 52,000 estrogen-regulated protein in benign breast diseases and other tissues by immunohistochemistry

1 reference

12 December 2020

A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.

1 reference

12 December 2020

Lysosomal Aspartic and Cysteine Proteinases Serum Levels in Patients with Pancreatic Cancer or Pancreatitis

1 reference

12 December 2020

Calciferin and cathepsin D-like acid protease in serum in acute and chronic liver injuries in rats and humans

1 reference

12 December 2020

Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.

1 reference

12 December 2020

Estrogen receptors and cathepsin D in human thyroid tissue.

1 reference

12 December 2020

High levels of proteolytic enzymes in the ascitic fluid and plasma of rats bearing the Yoshida AH-130 hepatoma

1 reference

12 December 2020

Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors

1 reference

12 December 2020

Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy

1 reference

12 December 2020

Expression of cathepsin D and estrogen receptor in male breast carcinoma

1 reference

12 December 2020

Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma

1 reference

12 December 2020

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

1 reference

12 December 2020

Molecular forms of β-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes

1 reference

12 December 2020

Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression

1 reference

12 December 2020

Predictive value of cathepsin-D for cervical lymph node metastasis in head and neck squamous cell carcinoma

1 reference

12 December 2020

Immunohistochemical and immunoradiometric evaluations of total cathepsin D in human larynx

1 reference

12 December 2020

Cathepsin D from Alzheimer's-Diseased and Normal Brains

1 reference

12 December 2020

Proteolytic Enzymes and Plasminogen Activator in Melanoma

1 reference

12 December 2020

Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases

1 reference

12 December 2020

Matrix metalloproteinases and cancer.

1 reference

12 December 2020

Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma

1 reference

12 December 2020

Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro.

1 reference

12 December 2020

Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer

1 reference

12 December 2020

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis

1 reference

12 December 2020

Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

1 reference

12 December 2020

Caspases: intracellular signaling by proteolysis

1 reference

12 December 2020

Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis

1 reference

12 December 2020

Endometrial adenocarcinoma of endometrioid subtype with squamous differentiation: an immunohistochemical study of MIB-1 (ki-67 paraffin), cathepsin D, and C-erbB-2 protein (p185)

1 reference

12 December 2020

Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices

1 reference

12 December 2020

Quantification of cathepsin D in plasma of patients with malignant melanoma

1 reference

12 December 2020

Cathepsin B, L, and D activities in colorectal carcinomas: relationship with clinico-pathological parameters

1 reference

12 December 2020

Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients

1 reference

12 December 2020

Cathepsin D expression in early cutaneous malignant melanoma

1 reference

12 December 2020

Cysteine proteinases in cancer progression and their clinical relevance for prognosis

1 reference

12 December 2020

Stromal cell cathepsin D expression and long-term survival in breast cancer

1 reference

12 December 2020

Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.

1 reference

12 December 2020

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1 reference

12 December 2020

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells

1 reference

12 December 2020

The distribution of cathepsin D in rat tissues determined by immunocytochemistry

1 reference

12 December 2020

Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors

1 reference

12 December 2020

Relationship between cathepsin-D content and disease-free survival in node-negative breast cancer patients: a meta-analysis.

1 reference

12 December 2020

[Cathepsin D activity in gastric cancer]

1 reference

12 December 2020

Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer

1 reference

12 December 2020

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha

1 reference

12 December 2020

Cellular distribution of cathepsin D in childhood tumors

1 reference

12 December 2020

Proteolytic enzymes at various stages of oncogenic transformation of rat fibroblasts. I. Aspartyl and cysteine proteinases.

1 reference

12 December 2020

Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness

1 reference

12 December 2020

Immunohistochemical localization of cathepsin D in colorectal tumors

1 reference

12 December 2020

Immunohistochemical analysis of cathepsin D in prostate carcinoma

1 reference

12 December 2020

Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors

1 reference

12 December 2020

Expression of cathepsin D in human astrocytic neoplasias.

1 reference

12 December 2020

Significance of cathepsin-D expression in uterine tumours

1 reference

12 December 2020

Enhanced acid protease activity of lysosomes from papillary thyroid carcinoma

1 reference

12 December 2020

Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells

1 reference

12 December 2020

Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation

1 reference

12 December 2020

Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells

1 reference

12 December 2020

Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostate

1 reference

12 December 2020

Immunohistochemical study on cathepsin-B and cathepsin-d in pancreatic-cancer

1 reference

12 December 2020

Lysosomal enzyme activities in normals and in patients with chronic liver diseases

1 reference

12 December 2020

Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer

1 reference

12 December 2020

Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells

1 reference

12 December 2020

Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection

1 reference

12 December 2020

Expression of cathepsin D during the progression of human gliomas.

1 reference

12 December 2020

Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.

1 reference

12 December 2020

Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma

1 reference

12 December 2020

Evaluation of cathepsin D immunostaining in colorectal adenocarcinoma

1 reference

12 December 2020

Prognostic significance of DNA ploidy, S-phase fraction, and tissue levels of aspartic, cysteine, and serine proteases in operable gastric carcinoma

1 reference

12 December 2020

Analysis of cathepsin D forms and their clinical implications in human prostate cancer

1 reference

12 December 2020

Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer

1 reference

12 December 2020

Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications

1 reference

12 December 2020

Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D

1 reference

12 December 2020

Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.

1 reference

12 December 2020

Prognostic Classification of Malignant Melanomas by Combining Clinical, Histological, and Immunohistochemical Parameters

1 reference

12 December 2020

Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells

1 reference

12 December 2020

Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells

1 reference

12 December 2020

Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma

1 reference

12 December 2020

Immunohistochemical expression of cathepsin D in meningiomas

1 reference

12 December 2020

Hydrolysis of androgen receptor by cathepsin D: its biological significance in human prostate cancer

1 reference

12 December 2020

Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns

1 reference

12 December 2020

Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells

1 reference

12 December 2020

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

1 reference

12 December 2020

Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters

1 reference

12 December 2020

Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland

1 reference

12 December 2020

Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis

1 reference

12 December 2020

Tissue cathepsins as tumor markers

1 reference

12 December 2020

Adhesive and invasive features in gliomas

1 reference

12 December 2020

The significance of metastasis-related factors cathepsin-D and nm23 in advanced ovarian cancer

1 reference

12 December 2020

Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis

1 reference

12 December 2020

Synthesis, maturation and extracellular release of procathepsin D as influenced by cell proliferation or transformation

1 reference

12 December 2020

Cathepsin D and PAI-1 expression in human head and neck cancer

1 reference

12 December 2020

Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1

1 reference

12 December 2020