(Q28265442)

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Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues

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Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues (English)

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G K Rekha

1

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V R Devaraj

2

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L Sreerama

3

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M J Lee

4

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H T Nagasawa

5

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N E Sladek

6

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publication date

15 February 1998

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Biochemical Pharmacology

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55

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465-74

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4

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Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance

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Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase

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Phenolic antioxidant-induced overexpression of class-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance.

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Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme

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Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol

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Effect of tolbutamide and chlorpropamide on acetaldehyde metabolism in two inbred strains of mice.

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N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase

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7 January 2021

N1-hydroxylated derivatives of chlorpropamide and its analogs as inhibitors of aldehyde dehydrogenase in vivo

1 reference

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Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase

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Aldehyde dehydrogenase. Covalent intermediate in aldehyde dehydrogenation and ester hydrolysis

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Cloning and expression of the full-length cDNAS encoding human liver class 1 and class 2 aldehyde dehydrogenase

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Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde

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Involvement of arginine residue in the phosphate binding site of human placental alkaline phosphatase

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The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes

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Statistical estimations in enzyme kinetics

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The role of the metal ion in the mechanism of the K+-activated aldehyde dehydrogenase of Saccharomyces cerevisiae

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Pharmacogenetics of aldehyde dehydrogenase (ALDH).

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Prodrugs of Nitroxyl as Potential Aldehyde Dehydrogenase Inhibitors vis-a-vis Vascular Smooth Muscle Relaxants

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10.1016/S0006-2952(97)00475-9

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