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PELP1: A novel therapeutic target for hormonal cancers
scientific article
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scholarly article
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review article
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stated in
Europe PubMed Central
title
PELP1: A novel therapeutic target for hormonal cancers
(English)
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main subject
cell biology
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clinical chemistry
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author name string
Dimple Chakravarty
series ordinal
1
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Rajeshwar Rao Tekmal
series ordinal
2
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Ratna K Vadlamudi
series ordinal
3
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language of work or name
English
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publication date
March 2010
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published in
IUBMB Life
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volume
62
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issue
3
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page(s)
162-9
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cites work
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling
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The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype
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Extranuclear coactivator signaling confers insensitivity to tamoxifen
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MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation
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20 March 2017
Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway
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Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells
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20 March 2017
Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor
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20 March 2017
Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
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Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2
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20 March 2017
9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway
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NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression
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Characterization of MNAR expression
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Functional implications of altered subcellular localization of PELP1 in breast cancer cells
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20 March 2017
Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets
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20 March 2017
Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.
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20 March 2017
Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors
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20 March 2017
Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
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20 March 2017
The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains
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20 March 2017
Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells
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20 March 2017
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes
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20 March 2017
Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway
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20 March 2017
Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc
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PubMed Central
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20 March 2017
Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein
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PubMed Central
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20 March 2017
MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions
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20 March 2017
Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha
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20 March 2017
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
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20 March 2017
Nuclear receptor coregulators: cellular and molecular biology
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7 April 2017
Estrogen receptors: how do they signal and what are their targets
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7 April 2017
Regulation of aromatase induction by nuclear receptor coregulator PELP1
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29 September 2017
Mechanisms involved in the regulation of histone lysine demethylases
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29 September 2017
MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997573
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29 September 2017
Estrogen receptor signaling pathways in human non-small cell lung cancer
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29 September 2017
Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase
1 reference
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PubMed Central
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29 September 2017
Cloning, distribution, and colocalization of MNAR/PELP1 with glucocorticoid receptors in primate and nonprimate brain
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29 September 2017
Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?
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29 September 2017
Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs).
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29 September 2017
Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR.
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29 September 2017
Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations
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29 September 2017
Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action
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29 September 2017
Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin
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29 September 2017
Estrogen rapid action via protein complex formation involving ERalpha and Src.
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29 September 2017
Intracellular signal transduction pathway proteins as targets for cancer therapy.
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29 September 2017
The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes
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29 September 2017
Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes
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29 September 2017
Novel estrogen receptor coregulators and signaling molecules in human diseases
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29 September 2017
Nongenomic actions of steroid hormones
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PubMed Central
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29 September 2017
RETRACTED: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997573
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29 September 2017
Minireview: aromatase and the regulation of estrogen biosynthesis--some new perspectives
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29 September 2017
Polysaccharide colloidal particles as delivery systems for macromolecules
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29 September 2017
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
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PubMed Central
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29 September 2017
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK.
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PubMed Central
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2 June 2018
Expression of ERalpha, ERbeta and co-regulator PELP1/MNAR in colorectal cancer: prognostic significance and clinicopathologic correlations.
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27 November 2018
Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis.
1 reference
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27 November 2018
Role of PELP1/MNAR signaling in ovarian tumorigenesis
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PubMed Central
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27 November 2018
Identifying the estrogen receptor coactivator PELP1 in autophagosomes.
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PubMed Central
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27 November 2018
Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.
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27 November 2018
Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor-induced apoptosis
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PubMed Central
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27 November 2018
Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
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PubMed Central
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27 November 2018
Identifiers
DOI
10.1002/IUB.287
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
731240
OpenCitations bibliographic resource ID
731240
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
731240
PMC publication ID
2997573
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
731240
PubMed publication ID
20014005
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
731240
ResearchGate publication ID
40691390
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