(Q28268181)

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

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title

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen (English)

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1 reference

D C Dahlin

1

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G T Miwa

series ordinal

2

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A Y Lu

series ordinal

3

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S D Nelson

series ordinal

4

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language of work or name

English

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publication date

March 1984

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published in

Proceedings of the National Academy of Sciences of the United States of America

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volume

81

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issue

5

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page(s)

1327-31

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cites work

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

29 September 2017

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

29 September 2017

Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

29 September 2017

Cumene hydroperoxide-supported microsomal hydroxylations of warfarin—A probe of cytochrome P-450 multiplicity and specificity

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

29 September 2017

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

2 June 2018

A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

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2 June 2018

Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

2 June 2018

N-Hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=344826

retrieved

27 November 2018

Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-hydroxyacetaminophen: A microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of evidence for N-hydroxyacetaminophen as a reactive metabolite of acetaminophen in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced hepatotoxicity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/6424115

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.81.5.1327

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

143019

ADS bibcode

1984PNAS...81.1327D

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OpenCitations bibliographic resource ID

143019

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

143019

PubMed publication ID

6424115

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

143019

ResearchGate publication ID

16772419

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(Q28268181)

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

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