(Q28273513)

2

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Ya-Ching Hsieh

3

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Chien-Yiu Huang

4

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Yi-Chen Lee

5

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Yun-Ju Chen

6

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Steven Lo

Journal of the National Cancer Institute

7

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language of work or name

English

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publication date

3 October 2012

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published in

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volume

104

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page(s)

1485-502

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issue

19

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cites work

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DNA-damage repair; the good, the bad, and the ugly

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Targeting the DNA damage response for cancer therapy

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Data from DNA repair studies questioned as leading researcher investigated.

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Current topics in DNA double-strand break repair

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DNA repair and chromosomal alterations

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Mechanisms of double-strand break repair in somatic mammalian cells

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MRE11/RAD50/NBS1: complex activities

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Regulation of DNA double-strand break repair pathway choice

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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

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Telomere dysfunction in genome instability syndromes.

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Telomeres: cancer to human aging

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The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

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The role of recombination in telomere length maintenance

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Roles of DNA repair proteins in telomere maintenance

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

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Isolation and characterization of the human MRE11 homologue

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The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes

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High visfatin expression in breast cancer tissue is associated with poor survival.

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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

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The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model

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Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis

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Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks

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The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay

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The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (chi2) not a gaussian distribution

21 January 2018

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A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species

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Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.

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Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene

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Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

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Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

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The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer

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DNA repair gene expression and risk of locoregional relapse in breast cancer patients.

21 January 2018

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MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer

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The inherited basis of human radiosensitivity

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ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance

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Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery

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Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo

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PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation

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Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.

21 January 2018

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