(Q28274789)

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RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

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Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination (English)

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

author name string

B H Lok

1

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

A C Carley

2

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

B Tchang

3

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

S N Powell

4

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Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

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publication date

10 September 2012

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Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

32

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

30

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

3552-3558

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5730454/fullTextXML

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Synthetic lethality--a new direction in cancer-drug development

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

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21 April 2017

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

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21 April 2017

Stimulation by Rad52 of yeast Rad51-mediated recombination

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Unraveling the mechanism of BRCA2 in homologous recombination

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Structure of the single-strand annealing domain of human RAD52 protein

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

https://api.crossref.org/works/10.1038/ONC.2012.391

21 April 2017

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.391

21 April 2017

The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Harnessing synthetic lethal interactions in anticancer drug discovery

1 reference

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2 June 2018

Mutational analysis of Brh2 reveals requirements for compensating mediator functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer.

1 reference

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2 June 2018

Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5730454

2 June 2018

A recurrent mutation in PALB2 in Finnish cancer families.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.391

21 January 2018

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.391

21 January 2018

Plasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic/Recurrent Nasopharyngeal Carcinoma

1 reference

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21 January 2018

Identifiers

10.1038/ONC.2012.391

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 January 2018

http://europepmc.org/abstract/PMC/5730454

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