(Q28278771)

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Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities

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Europe PubMed Central

Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities (English)

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author name string

Elizabeth A Tengstrand

1

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Gerald T Miwa

2

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Frank Y Hsieh

3

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language of work or name

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publication date

May 2010

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Expert Opinion on Drug Metabolism & Toxicology

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6

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5

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555-70

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Drug-induced phospholipidosis

1 reference

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Drug-induced phospholipidosis: issues and future directions

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The LDL receptor

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Autophagy in the Pathogenesis of Disease

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21 April 2017

Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis

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21 April 2017

Subchronic pulmonary inflammation and fibrosis induced by silica in rats are attenuated by amiodarone

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21 April 2017

Studies on drug-induced lipidosis: VII. Effects of bis-beta-diethyl-aminoethylether of hexestrol, chloroquine, homochlorocyclizine, prenylamine, and diazacholesterol on the lipid composition of rat liver and kidney

1 reference

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21 April 2017

Biomarkers to monitor drug-induced phospholipidosis

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21 April 2017

Role of LBPA and Alix in multivesicular liposome formation and endosome organization

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21 April 2017

Regulation of sterol transport between membranes and NPC2

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21 April 2017

Chloroquine myopathy.

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21 April 2017

A morphologic and cytochemical study on the great alveolar cell

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21 January 2018

Drug-induced Phospholipidosis -Pathological Aspects and Its Prediction

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21 January 2018

Amiodarone--an inhibitor of phospholipase activity: a comparative study of the inhibitory effects of amiodarone, chloroquine and chlorpromazine

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21 January 2018

The presence of abnormal lysosomes in lymphocytes and neutrophils during chloroquine therapy: a quantitative ultrastructural study

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21 January 2018

Urinary Myelin Figures in Gentamicin Nephrotoxicity

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21 January 2018

Lipidosis induced by amphiphilic cationic drugs

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21 January 2018

A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system

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21 January 2018

Proteomic analysis of phospholipidosis in citalopram treated U937 cells--support for the cholesterol biosynthesis hypothesis.

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21 January 2018

Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes

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21 January 2018

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology.

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21 January 2018

Commentary. Lysosomotropic agents

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21 January 2018

Morphological, biochemical and molecular biology approaches for the diagnosis of lysosomal storage diseases

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21 January 2018

Niemann-Pick type C mutations cause lipid traffic jam.

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21 January 2018

Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport

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21 January 2018

Role of cholesterol and lipid organization in disease

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21 January 2018

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport.

1 reference

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21 January 2018

Roles and regulation of secretory and lysosomal acid sphingomyelinase

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21 January 2018

Accumulation of a glycerolphospholipid in classical niemann-pick disease

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21 January 2018

Niemann‐Pick disease type C: An update

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Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids

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21 January 2018

The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase

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21 January 2018

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

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21 January 2018

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

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21 January 2018

Fluorescence studies on binding of amphiphilic drugs to isolated lamellar bodies: relevance to phospholipidosis

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21 January 2018

The production and elimination of myeloid bodies by cultured pancreatic islet cells

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21 January 2018

Pulmonary and generalized lysosomal storage induced by amphiphilic drugs

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21 January 2018

Aminoglycoside-induced renal phospholipidosis and nephrotoxicity

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21 January 2018

Characterisation of a potential biomarker of phospholipidosis from amiodarone-treated rats

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21 January 2018

Biosynthetic conversion of phosphatidylglycerol to sn-1:sn-1' bis(monoacylglycerol) phosphate in a macrophage-like cell line

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21 January 2018

Formation of bis(monoacylglycero)phosphate by a macrophage transacylase

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21 January 2018

Lipids in endocytic membrane transport and sorting

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21 January 2018

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

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21 January 2018

Degradation of membrane-bound ganglioside GM2 by beta -hexosaminidase A. Stimulation by GM2 activator protein and lysosomal lipids

1 reference

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21 January 2018

Lysosomal degradation on vesicular membrane surfaces. Enhanced glucosylceramide degradation by lysosomal anionic lipids and activators.

1 reference

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21 January 2018

Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP.

1 reference

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21 January 2018

Interfacial regulation of acid ceramidase activity. Stimulation of ceramide degradation by lysosomal lipids and sphingolipid activator proteins

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Lysobisphosphatidic acid controls endosomal cholesterol levels

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Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly.

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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21 January 2018

Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy.

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21 January 2018

Histological and ultrastructural findings in chloroquine-induced cardiomyopathy.

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21 January 2018

Cardiomyopathy related to antimalarial therapy with illustrative case report

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21 January 2018

New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy--a report of 2 cases

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Phospholipid metabolite 1-palmitoyl-lysophosphatidylcholine enhances human ether-a-go-go-related gene (HERG) K(+) channel function

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Molecular analysis of PIP2 regulation of HERG and IKr.

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Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells.

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Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients

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Chloroquine myopathy and myasthenia-like syndrome.

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21 January 2018

Early detection of acute kidney injury: emerging new biomarkers.

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21 January 2018

Assessment of renal injury in vivo

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A clinical flow cytometric biomarker strategy: validation of peripheral leukocyte phospholipidosis using Nile red.

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Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring

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Endosome marker is fat not fiction

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21 January 2018

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10.1517/17425251003601961

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