(Q28286012)

English

Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex

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scholarly article

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Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex (English)

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lipopolysaccharide

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toll-like receptor

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author name string

Diana Rose E Ranoa

1

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Stacy L Kelley

2

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Richard I Tapping

3

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language of work or name

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publication date

5 April 2013

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Journal of Biological Chemistry

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288

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14

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9729-41

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The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket

1 reference

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Approaching the asymptote: 20 years later

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20 March 2017

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

1 reference

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20 March 2017

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

1 reference

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20 March 2017

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

1 reference

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20 March 2017

Pathogen recognition and innate immunity

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20 March 2017

Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein

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20 March 2017

Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanism

1 reference

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20 March 2017

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Discrimination of bacterial lipoproteins by Toll-like receptor 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

1 reference

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20 March 2017

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Structure and function of lipopolysaccharide binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 March 2017

Toll-like receptor control of the adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

7 April 2017

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

7 April 2017

The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Structures of the toll-like receptor family and its ligand complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

TLR2 recognizes a bacterial lipopeptide through direct binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Structures in Bacillus subtilis are recognized by CD14 in a lipopolysaccharide binding protein-dependent reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Recognition of gram-negative bacteria and endotoxin by the innate immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Biological activities of native and recombinant Borrelia burgdorferi outer surface protein A: dependence on lipid modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

29 September 2017

Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

2 June 2018

OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

2 June 2018

Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

20 June 2018

Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.453266

21 January 2018

Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.453266

21 January 2018

Essential role of MD-2 in LPS responsiveness and TLR4 distribution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

27 November 2018

The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617275

27 November 2018

LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum CD14 levels in poly traumatized and severely burned patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide toxicity-regulating proteins in bacteremia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of surface CD14 on human monocytes and neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycobacterium avium infection in CD14-deficient mice fails to substantiate a significant role for CD14 in antimycobacterial protection or granulomatous inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23430250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.453266

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