(Q28288262)

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Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein

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Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein (English)

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author name string

Jianguo Liu

1

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Xiuqin Guan

2

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Tomohiko Tamura

3

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Keiko Ozato

4

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Xiaojing Ma

5

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language of work or name

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publication date

31 December 2004

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Journal of Biological Chemistry

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279

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53

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55609-17

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IRF family of transcription factors as regulators of host defense

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Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

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Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells

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Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1

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c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

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Human IL-12(p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Sp1-binding sites

1 reference

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IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 promoter activity in macrophages

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An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages

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Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologies

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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Biosynthesis and posttranslational regulation of human IL-12.

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Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering

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Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

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Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.

1 reference

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Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

1 reference

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Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

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