(Q28294687)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

review article

1 reference

title

Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Antimalarial Activity of Artemisinin (Qinghaosu) and Related Trioxanes: Mechanism (s) of Action (English)

0 references

0 references

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Cumming JN

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Ploypradith P

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Posner GH

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

Jared N. Cumming

1

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Poonsakdi Ploypradith

2

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Gary H. Posner

3

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language of work or name

English

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publication date

1 January 1997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

1996

0 references

published in

Advances in Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

20 October 2019

page(s)

253-297

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8891104%20AND%20SRC:MED&resulttype=core&format=json

Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives

20 October 2019

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Reaction of antimalarial endoperoxides with specific parasite proteins

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7 January 2021

Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin

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7 January 2021

Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture.

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Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria

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7 January 2021

Desferrioxamine protects human red blood cells from hemin-induced hemolysis

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7 January 2021

Cerebral malaria: the sequestration hypothesis.

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7 January 2021

Neurotoxicity in animals due to arteether and artemether.

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7 January 2021

Arteether, a new antimalarial drug: synthesis and antimalarial properties.

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A Plasmodium falciparum malaria vaccine candidate which contains epitopes from the circumsporozoite protein and a blood stage antigen, 5.1.

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7 January 2021

Identification of the in vivo metabolites of the antimalarial arteether by thermospray high-performance liquid chromatography/mass spectrometry

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7 January 2021

The cytokine theory of human cerebral malaria.

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7 January 2021

Malaria: current and future prospects for control

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7 January 2021

Plasmodium falciparum (human malaria)-induced modifications in human erythrocyte band 3 protein

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7 January 2021

Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver

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7 January 2021

The toxicity of artemisinin and related compounds on neuronal and glial cells in culture

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7 January 2021

Spin trapping in biological systems. Oxidation of the spin trap 5,5-dimethyl-1-pyrroline-1-oxide by a hydroperoxide-hematin system

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7 January 2021

Morphological changes of clefts in Plasmodium-infected erythrocytes under adverse conditions.

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7 January 2021

In-vitro resistance of Plasmodium falciparum to qinghaosu derivatives in west Africa

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7 January 2021

Selectivity properties of pores induced in host erythrocyte membrane by Plasmodium falciparum. Effect of parasite maturation.

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7 January 2021

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle

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7 January 2021

In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy

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7 January 2021

Cerebral malaria: mediators, mechanical obstruction or more?

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7 January 2021

Tumor necrosis factor and disease severity in children with falciparum malaria.

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7 January 2021

Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr1 gene

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7 January 2021

The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)

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7 January 2021

The behaviour of qinghaosu (artemisinin) in the presence of non-heme iron(II) and (III)

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7 January 2021

An overview of the clinical use of artemisinin and its derivatives in the treatment of falciparum malaria in Viet Nam.

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7 January 2021

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7 January 2021

Amplification of cytoadherence in cerebral malaria: towards a more rational explanation of disease pathophysiology

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7 January 2021

The interaction of artemisinin with malarial hemozoin.

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7 January 2021

Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.

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7 January 2021

Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model.

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7 January 2021

Synthesis and antimalarial activity of (+)-deoxoartemisinin

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7 January 2021

An antimalarial peroxide from Amomum krervanh Pierre

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7 January 2021

Chemical characterization of the parasitophorous vacuole membrane antigen QF 116 from Plasmodium falciparum

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7 January 2021

Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria

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7 January 2021

Microbial and mammalian metabolism studies on the semisynthetic antimalarial, deoxoartemisinin

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7 January 2021

Characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum

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7 January 2021

Qinghaosu (artemisinin): an antimalarial drug from China

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7 January 2021

Epidemiological evidence for an association between chloroquine resistance of Plasmodium falciparum and its immunological properties

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7 January 2021

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

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7 January 2021

Malarial toxins and the regulation of parasite density

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7 January 2021

TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria.

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7 January 2021

Proton NMR characterization of the ferryl group in model heme complexes and hemoproteins: evidence for the FeIVO group in ferryl myoglobin and compound II of horseradish peroxidase

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7 January 2021

Metabolism of antimalarial sesquiterpene lactones.

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7 January 2021

Microbial metabolism studies of the antimalarial sesquiterpene artemisinin

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7 January 2021

Plasmodium falciparum malaria: association of knobs on the surface of infected erythrocytes with a histidine-rich protein and the erythrocyte skeleton

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7 January 2021

Clinical trials of artemisinin and its derivatives in the treatment of malaria in China

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7 January 2021

Antimalarial activity of new water-soluble dihydroartemisinin derivatives

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7 January 2021

Overview of clinical studies on artemisinin derivatives in Thailand

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7 January 2021

The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives

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7 January 2021

Morphologic effects of artemisinin in Plasmodium falciparum

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7 January 2021

Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450.

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7 January 2021

Indicators of life-threatening malaria in African children

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7 January 2021

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

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7 January 2021

Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

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7 January 2021

Distribution of mature trophozoites and schizonts of Plasmodium falciparum in the organs of Aotus trivirgatus, the night monkey.

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7 January 2021

Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine

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7 January 2021

Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria

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7 January 2021

Malaria, the submerged disease

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7 January 2021

Squalene epoxidase from rat liver microsomes

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7 January 2021

Hemozoin production by Plasmodium falciparum: variation with strain and exposure to chloroquine.

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7 January 2021

The promise of asexual malaria vaccine development.

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7 January 2021

The prevention of antimalarial drug resistance

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7 January 2021

The chemotherapy of rodent malaria. XLVIII. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 1: Studies leading to the development of novel cis-fused cyclopenteno derivatives

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7 January 2021

The chemotherapy of rodent malaria. XLIX. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 2: Structure-activity studies on cis-fused cyclopenteno-1,2,4-trioxanes (fenozans) aga

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7 January 2021

The chemotherapy of rodent malaria. L. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 3: Observations on 'Fenozan-50F', a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane.

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7 January 2021

Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes

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7 January 2021

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity

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7 January 2021

Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.

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7 January 2021

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin

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7 January 2021

Synthesis and antimalarial activities of 12 beta-allyldeoxoartemisinin and its derivatives.

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7 January 2021

The Role of Pyrrole Formation in the Alteration of Neurofilament Transport Induced during Exposure to 2,5-Hexanedione

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7 January 2021

Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine.

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7 January 2021

Malarial pigment-dependent error in the estimation of hemoglobin content in Plasmodium falciparum-infected red cells: implications for metabolic and biochemical studies of the erythrocytic phases of malaria.

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7 January 2021

Antimalarial activity of some natural peroxides

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7 January 2021

Artemether in moderately severe and cerebral malaria in Nigerian children

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7 January 2021

Total synthesis of qinghaosu

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7 January 2021

Differential sequestration of parasitized erythrocytes in the cerebrum and cerebellum in human cerebral malaria.

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7 January 2021

Current trends in new drug research in the People's Republic of China

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7 January 2021

Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum

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7 January 2021

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

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7 January 2021

Structural diversity in the 45-kilodalton merozoite surface antigen of Plasmodium falciparum.

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7 January 2021

Cerebral malaria in children

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7 January 2021

Inhibition of hemin-induced hemolysis by desferrioxamine: binding of hemin to red cell membranes and the effects of alteration of membrane sulfhydryl groups

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7 January 2021

Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide

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7 January 2021

Preliminary report on the use of desferrioxamine in the treatment ofPlasmodium falciparum malaria

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7 January 2021

Prostacyclin and Thromboxane Synthase: New Aspects of Hemethiolate Catalysis

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7 January 2021

Antimalarial activity of novel ring-contracted artemisinin derivatives

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7 January 2021

High-valent intermediates in the reaction of Nα-acetyl microperoxidase-8 with hydrogen peroxide: Models for compounds 0,I and II of horseradish peroxidase

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7 January 2021

Pathophysiology of severe falciparum malaria in man.

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7 January 2021

Chloroquine resistance of Plasmodium falciparum: a biological advantage?

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7 January 2021

Neurotoxicity of artemisinin analogs in vitro

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7 January 2021

Artemisinin: current status

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7 January 2021

Total synthesis of (+)-Yingzhaosu A

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7 January 2021

Alkylation of human albumin by the antimalarial artemisinin

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7 January 2021

Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure

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7 January 2021

Energies of Activation. The Paradigm of Hydrogen Abstractions by Radicals

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7 January 2021

10.1016/S1054-3589(08)60952-7

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release_jwjkqhrznzcqtdpzkrxwe7obri

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https://api.fatcat.wiki/v0/release/jwjkqhrznzcqtdpzkrxwe7obri

24 November 2022

mapped directly with Wikidata item

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