(Q28295447)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892893%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death (English)

1 reference

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6 March 2020

1 reference

1 reference

19

1 reference

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6 March 2020

Thomas O'Brien

22

1 reference

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6 March 2020

author name string

Paola Magnaghi

1

1 reference

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6 March 2020

Roberto D'Alessio

2

1 reference

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6 March 2020

Barbara Valsasina

3

1 reference

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6 March 2020

Nilla Avanzi

4

1 reference

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6 March 2020

Simona Rizzi

5

1 reference

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6 March 2020

Daniela Asa

6

1 reference

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6 March 2020

Fabio Gasparri

7

1 reference

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6 March 2020

Liviana Cozzi

8

1 reference

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6 March 2020

Ulisse Cucchi

9

1 reference

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6 March 2020

Christian Orrenius

10

1 reference

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6 March 2020

Paolo Polucci

11

1 reference

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6 March 2020

Dario Ballinari

12

1 reference

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6 March 2020

Claudia Perrera

13

1 reference

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6 March 2020

Antonella Leone

14

1 reference

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6 March 2020

Giovanni Cervi

15

1 reference

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6 March 2020

Elena Casale

16

1 reference

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6 March 2020

Yang Xiao

17

1 reference

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6 March 2020

Chihunt Wong

18

1 reference

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6 March 2020

Arturo Galvani

20

1 reference

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6 March 2020

Daniele Donati

21

1 reference

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6 March 2020

Peter K Jackson

23

1 reference

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6 March 2020

Antonella Isacchi

24

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

28 July 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892893%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

published in

Nature Chemical Biology

1 reference

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6 March 2020

volume

9

1 reference

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6 March 2020

issue

9

1 reference

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6 March 2020

page(s)

548-556

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892893%20AND%20SRC:MED&resulttype=core&format=json

AAA+ superfamily ATPases: common structure--diverse function

6 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Nucleotide dependent motion and mechanism of action of p97/VCP

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Conformational changes in the AAA ATPase p97-p47 adaptor complex

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Inhibition of p97-dependent protein degradation by Eeyarestatin I

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

The crystal structure of murine p97/VCP at 3.6A

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

HDAC6-p97/VCP controlled polyubiquitin chain turnover

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1313

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Ubiquitin receptors and ERAD: a network of pathways to the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Development of p97 AAA ATPase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Regulation of autophagy by ATF4 in response to severe hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

21 January 2018

1 reference

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Dominant-negative effect of mutant valosin-containing protein in aggresome formation

21 January 2018

1 reference

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Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1313

Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23892893

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23892893

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1313

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23892893%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017