(Q28306596)

2

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author name string

Jonathan A Roberts

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Helen R Digby

3

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Kelvin C Agboh

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Hairuo Wen

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Amelia Atterbury-Thomas

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Richard J Evans

Molecular physiology of P2X receptors

7

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language of work or name

English

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publication date

August 2006

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published in

Pfluegers Archiv

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volume

452

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issue

5

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page(s)

486-500

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cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Control of P2X(2) channel permeability by the cytosolic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Comparison of adenosine triphosphate- and nicotine-activated inward currents in rat phaeochromocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Inhibitory interactions between 5-HT3 and P2X channels in submucosal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Extracellular ATP: effects, sources and fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0073-6

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

21 January 2018

1 reference

12 December 2020

Heterogeneity of P2X receptors in sympathetic neurons: contribution of neuronal P2X1 receptors revealed using knockout mice

1 reference

12 December 2020

Molecular physiology of P2X receptors and ATP signalling at synapses

1 reference

12 December 2020

Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype

1 reference

12 December 2020

Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit

1 reference

12 December 2020

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor.

1 reference

12 December 2020

Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice

1 reference

12 December 2020

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

1 reference

12 December 2020

Use-dependent inhibition of P2X3 receptors by nanomolar agonist.

1 reference

12 December 2020

Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.

1 reference

12 December 2020

Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function

1 reference

12 December 2020

The Protein Data Bank

1 reference

12 December 2020

A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia

1 reference

12 December 2020

Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

1 reference

12 December 2020

Single channel properties of P2X2 purinoceptors

1 reference

12 December 2020

Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits

1 reference

12 December 2020

Localization and functional expression of splice variants of the P2X2 receptor

1 reference

12 December 2020

P2X(1) receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries

1 reference

12 December 2020

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1 reference

12 December 2020

Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor.

1 reference

12 December 2020

Lipid rafts: heterogeneity on the high seas

1 reference

12 December 2020

Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts

1 reference

12 December 2020

Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites

1 reference

12 December 2020

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

1 reference

12 December 2020

Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase

1 reference

12 December 2020

Density-dependent changes of the pore properties of the P2X2 receptor channel

1 reference

12 December 2020

Potential therapeutic targets in the rapidly expanding field of purinergic signalling.

1 reference

12 December 2020

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1 reference

12 December 2020

Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones

1 reference

12 December 2020

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH

1 reference

12 December 2020

Identification of a tubulin binding motif on the P2X2 receptor.

1 reference

12 December 2020

1 reference

12 December 2020

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

1 reference

12 December 2020

Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus

1 reference

12 December 2020

Structure and function of AMPA receptors

1 reference

12 December 2020

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1 reference

12 December 2020

State-dependent cross-inhibition between transmitter-gated cation channels.

1 reference

12 December 2020

Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors

1 reference

12 December 2020

Molecular assembly of the extracellular domain of P2X2, an ATP-gated ion channel

1 reference

12 December 2020

ATP binding site of P2X channel proteins: structural similarities with class II aminoacyl-tRNA synthetases

1 reference

12 December 2020

Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface

1 reference

12 December 2020

Expression level dependent changes in the properties of P2X2 receptors.

1 reference

12 December 2020

Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners

1 reference

12 December 2020

Sensitization by extracellular Ca(2+) of rat P2X(5) receptor and its pharmacological properties compared with rat P2X(1)

1 reference

12 December 2020

A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization.

1 reference

12 December 2020

P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle

1 reference

12 December 2020

A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor

1 reference

12 December 2020

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes.

1 reference

12 December 2020

Mutagenesis studies of conserved proline residues of human P2X receptors for ATP indicate that proline 272 contributes to channel function

1 reference

12 December 2020

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1 reference

12 December 2020

An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy.

1 reference

12 December 2020

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

1 reference

12 December 2020

Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice

1 reference

12 December 2020

Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize

1 reference

12 December 2020

The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis

1 reference

12 December 2020

P2X receptor subtype-specific modulation of excitatory and inhibitory synaptic inputs in the rat brainstem.

1 reference

12 December 2020

A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X(2) ATP-gated channels

1 reference

12 December 2020

Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles

1 reference

12 December 2020

Lack of run-down of smooth muscle P2X receptor currents recorded with the amphotericin permeabilized patch technique, physiological and pharmacological characterization of the properties of mesenteric artery P2X receptor ion channels

1 reference

12 December 2020

Conserved negatively charged residues are not required for ATP action at P2X(1) receptors

1 reference

12 December 2020

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia

1 reference

12 December 2020

ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists

1 reference

12 December 2020

Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels

1 reference

12 December 2020

Agonist-dependence of recovery from desensitization of P2X(3) receptors provides a novel and sensitive approach for their rapid up or downregulation

1 reference

12 December 2020

Regulation of human recombinant P2X3 receptors by ecto-protein kinase C.

1 reference

12 December 2020

Intracellular cross talk and physical interaction between two classes of neurotransmitter-gated channels.

1 reference

12 December 2020

Pharmacology of cloned P2X receptors

1 reference

12 December 2020

Interaction between cysteines introduced into each transmembrane domain of the rat P2X2 receptor

1 reference

12 December 2020

Mechanism of ivermectin facilitation of human P2X4 receptor channels

1 reference

12 December 2020

Altered cytokine production in mice lacking P2X(7) receptors

1 reference

12 December 2020

Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor

1 reference

12 December 2020

Activation and Desensitization of the Recombinant P2X1 Receptor at Nanomolar ATP Concentrations

1 reference

12 December 2020

Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function

1 reference

12 December 2020

Allosteric control of gating and kinetics at P2X(4) receptor channels

1 reference

12 December 2020

Desensitization masks nanomolar potency of ATP for the P2X1 receptor

1 reference

12 December 2020

Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system

1 reference

12 December 2020

Non-additive interaction between nicotinic cholinergic and P2X purine receptors in guinea-pig enteric neurons in culture

1 reference

12 December 2020

Central P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor.

1 reference

12 December 2020

Point mutations confer loss of ATP-induced human P2X(7) receptor function

1 reference

12 December 2020

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

1 reference

12 December 2020

Membrane topology of an ATP-gated ion channel (P2X receptor).

1 reference

12 December 2020

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

1 reference

12 December 2020

The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones

1 reference

12 December 2020

ATP is a mediator of chemosensory transduction in the central nervous system

1 reference

12 December 2020

Molecular dissection of purinergic P2X receptor channels.

1 reference

12 December 2020

ATP signaling is crucial for communication from taste buds to gustatory nerves

1 reference

12 December 2020

Functional interactions between nicotinic and P2X channels in short-term cultures of guinea-pig submucosal neurons

1 reference

12 December 2020

A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo

1 reference

12 December 2020

Purification and aqueous phase atomic force microscopic observation of recombinant P2X2 receptor

1 reference

12 December 2020

Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype

1 reference

12 December 2020

The role of positively charged amino acids in ATP recognition by human P2X(1) receptors.

1 reference

12 December 2020

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

1 reference

12 December 2020

Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction

1 reference

12 December 2020

G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation

1 reference

12 December 2020

Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors.

1 reference

12 December 2020

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

1 reference

12 December 2020

An intersubunit zinc binding site in rat P2X2 receptors

1 reference

12 December 2020

Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization.

1 reference

12 December 2020

Molecular determinants of the agonist binding domain of a P2X receptor channel.

1 reference

12 December 2020

ATP-activated current and its interaction with acetylcholine-activated current in rat sympathetic neurons

1 reference

12 December 2020

P2X receptors bring new structure to ligand-gated ion channels

1 reference

12 December 2020

Facilitation by 5-hydroxytryptamine of ATP-activated current in rat pheochromocytoma cells

1 reference

12 December 2020

Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors

1 reference

12 December 2020

Proteomic and functional evidence for a P2X7 receptor signalling complex

1 reference

12 December 2020

Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors

1 reference

12 December 2020

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

1 reference

12 December 2020

Subunit Arrangement in P2X Receptors

1 reference

12 December 2020

Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors

1 reference

12 December 2020

Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin

1 reference

12 December 2020

Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes

1 reference

12 December 2020

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits

1 reference

12 December 2020

Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors

1 reference

12 December 2020

Desensitization, recovery and Ca(2+)-dependent modulation of ATP-gated P2X receptors in nociceptors

1 reference

12 December 2020

ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics

1 reference

12 December 2020

Effects of enhanced P2X1 receptor Ca2+ influx on functional responses in human platelets.

1 reference

12 December 2020

Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors

1 reference

12 December 2020

Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels.

1 reference

12 December 2020

Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C.

1 reference

12 December 2020

ATP modulation of excitatory synapses onto interneurons

1 reference

12 December 2020

P2X3 receptor localizes into lipid rafts in neuronal cells

1 reference

12 December 2020

An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor

1 reference

12 December 2020

Distinct ATP receptors on pain-sensing and stretch-sensing neurons.

1 reference

12 December 2020

Intracellular calcium changes trigger connexin 32 hemichannel opening

1 reference

12 December 2020

Negative cross talk between anionic GABAA and cationic P2X ionotropic receptors of rat dorsal root ganglion neurons.

1 reference

12 December 2020

Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium

1 reference

12 December 2020

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine

1 reference

12 December 2020

Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor

1 reference

12 December 2020

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

1 reference

12 December 2020

Identification of a domain involved in ATP-gated ionotropic receptor subunit assembly

1 reference

12 December 2020

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1 reference

12 December 2020

P2X(1) receptor subunit contribution to gating revealed by a dominant negative PKC mutant

1 reference

12 December 2020

The P2X3 antagonist P1, P5-di[inosine-5'] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons

1 reference

12 December 2020

Molecular structure of P2X receptors

1 reference

12 December 2020

Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP.

1 reference

12 December 2020

Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear

1 reference

12 December 2020

Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.

1 reference

12 December 2020

Desensitization of the P2X(2) receptor controlled by alternative splicing

1 reference

12 December 2020

Molecular properties of ATP-gated P2X receptor ion channels

1 reference

12 December 2020

Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain

1 reference

12 December 2020

Mutual occlusion of P2X ATP receptors and nicotinic receptors on sympathetic neurons of the guinea-pig

1 reference

12 December 2020

siRNA relieves chronic neuropathic pain

1 reference

12 December 2020

Properties of the novel ATP-gated ionotropic receptor composed of the P2X(1) and P2X(5) isoforms

1 reference

12 December 2020

Reanalysis of P2X7 receptor expression in rodent brain

1 reference

12 December 2020

Pharmacological and biophysical properties of the human P2X5 receptor

1 reference

12 December 2020

Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit

1 reference

12 December 2020

Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes

1 reference

12 December 2020

Domains of P2X receptors involved in desensitization

1 reference

12 December 2020

Renal autoregulation in P2X1 knockout mice.

1 reference

12 December 2020

Characterization of cultured dorsal root ganglion neuron P2X receptors

1 reference

12 December 2020

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

1 reference

12 December 2020

An evaluation of antibody detection of the P2X1 receptor subunit in the CNS of wild type and P2X1-knockout mice.

1 reference

12 December 2020

Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors.

1 reference

12 December 2020