(Q28315009)

English

Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus

scientific article (publication date: December 2004)

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scholarly article

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Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus (English)

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human nutrition

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type 2 diabetes

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

author name string

L Heilbronn

1

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S R Smith

2

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E Ravussin

3

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language of work or name

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publication date

December 2004

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International Journal of Obesity

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28

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S12-S21

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Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994.

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21 January 2018

LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective

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21 January 2018

Banting lecture 1988. Role of insulin resistance in human disease

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21 January 2018

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

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21 January 2018

Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism

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21 January 2018

Splanchnic glucose and amino acid metabolism in obesity

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21 January 2018

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors

1 reference

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21 January 2018

Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?

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21 January 2018

Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women.

1 reference

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21 January 2018

Fuel selection in human skeletal muscle in insulin resistance: a reexamination

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21 January 2018

Free fatty acids and pathogenesis of type 2 diabetes mellitus

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21 January 2018

Relationships of generalized and regional adiposity to insulin sensitivity in men.

1 reference

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21 January 2018

Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat.

1 reference

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21 January 2018

Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity

1 reference

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21 January 2018

Insulin sensitivity and serum triglyceride level in obese white and black women: relationship to visceral and truncal subcutaneous fat.

1 reference

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21 January 2018

Role of muscle in triglyceride metabolism.

1 reference

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21 January 2018

Cellular mechanisms of insulin resistance

1 reference

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21 January 2018

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

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21 January 2018

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

1 reference

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21 January 2018

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

1 reference

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21 January 2018

Effects of weight loss on regional fat distribution and insulin sensitivity in obesity

1 reference

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21 January 2018

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

1 reference

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21 January 2018

Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes

1 reference

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21 January 2018

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

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21 January 2018

Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes.

1 reference

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21 January 2018

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

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21 January 2018

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

1 reference

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21 January 2018

Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Cellular basis of insulin insensitivity in large rat adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Transcriptional control of adipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Multilineage potential of adult human mesenchymal stem cells

1 reference

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21 January 2018

Molecular regulation of adipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

PPARgamma, the ultimate thrifty gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade.

1 reference

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21 January 2018

Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis

1 reference

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21 January 2018

Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance

1 reference

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21 January 2018

Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI/S studies in Zucker fatty rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

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21 January 2018

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

1 reference

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21 January 2018

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

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21 January 2018

Identification of a biochemical link between energy intake and energy expenditure

1 reference

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21 January 2018

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

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21 January 2018

Demonstration of an in vivo functional beta 3-adrenoceptor in man

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Respiratory quotient is inversely associated with muscle sympathetic nerve activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

1 reference

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21 January 2018

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

De novo formation of adipose tissue by controlled release of basic fibroblast growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Positional cloning of the mouse obese gene and its human homologue

1 reference

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21 January 2018

Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes: a paracrine signal for preadipocyte growth

1 reference

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21 January 2018

Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth

1 reference

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21 January 2018

Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease

1 reference

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21 January 2018

Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.

1 reference

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21 January 2018

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Tissue-specific regulation of fat cell lipolysis by NPY in 6-OHDA-treated rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

The Role of Melanocortins in Adipocyte Function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Inhibition of adipogenesis by Wnt signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Circulating ghrelin levels are decreased in human obesity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor

1 reference

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21 January 2018

IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes

1 reference

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21 January 2018

The respiratory quotient as a prognostic factor in weight-loss rebound

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

21 January 2018

Diabetes incidence in Pima indians: contributions of obesity and parental diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Fat distribution and health in obesity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Regional adiposity and morbidity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Heterogeneity of pig intestinal D-glucose transport systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of diet on thermogenesis in acquired lipodystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial partial lipodystrophy: complications of obesity in the non-obese?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of troglitazone on body fat distribution in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin Secretion in Relation to Adipose Tissue in Men

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Please pass the chips: genomic insights into obesity and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Fat and carbohydrate balances during adaptation to a high-fat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Human skeletal muscle carnitine palmitoyltransferase I activity determined in isolated intact mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Adaptations of skeletal muscle to endurance exercise and their metabolic consequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Dobutamine as selective beta(1)-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal A1 adenosine receptor function in genetic obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Angiotensinogen, angiotensin II and adipose tissue development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Upregulation of bone morphogenetic protein GDF-3/Vgr-2 expression in adipose tissue of FABP4/aP2 null mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin-like growth factor 1 induction of differentiation of porcine preadipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-8 production in human adipose tissue. inhibitory effects of anti-diabetic compounds, the thiazolidinedione ciglitazone and the biguanide metformin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Function of pref-1 as an inhibitor of adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.IJO.0802853

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic, psychological, and health correlates of dietary restraint in healthy postmenopausal women

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.IJO.0802853

1 reference

Consolidated OpenCitations Corpus – April 2017

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release_d76yv56ovrgyhb3j2qcqugyjmy

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

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Springer Nature article ID

10.1038/sj.ijo.0802853

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