(Q28329448)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

review article

1 reference

title

Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

1 reference

D. E. Drayer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A799549

29 July 2022

language of work or name

English

0 references

publication date

1 November 1976

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacokinetics

14 September 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

page(s)

426-443

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:799549%20AND%20SRC:MED&resulttype=core&format=json

Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses

14 September 2019

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12 December 2020

Conversion of cortisone to cortisol and prednisone to prednisolone

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12 December 2020

Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references

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The fate of guanethidine in two hypertensive patients

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N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans

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The convulsant potency of lidocaine and its N-dealkylated metabolites

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Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamide

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12 December 2020

Utility of clinical chemical determinations of drug concentrations in biological fluids

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Identification and activity of the hydroxy metabolite that accumulates in the plasma of humans intoxicated with glutethimide

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12 December 2020

Teratogenic and other effects produced in mice by norethynodrel and its 3-hydroxymetabolites.

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12 December 2020

Stereospecific synthesis of the 6.beta.-hydroxy metabolites of naltrexone and naloxone

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12 December 2020

Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites

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12 December 2020

Metabolic conversion of primidone (mysoline) to phenobarbital

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12 December 2020

Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man

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12 December 2020

Plasma concentrations of diazepam and of its metaboliteN-desmethyldiazepam in relation to anxiolytic effect

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12 December 2020

Studies on the metabolism in man of oxisuran, a differential immunosuppressive drug

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12 December 2020

Action of 1,25-dihydroxycholecalciferol, a potent, kidney-produced metabolite of vitamin D, in uremic man.

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Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration

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12 December 2020

Central nervous system effects and metabolic disposition of a glycol metabolite of propranolol

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12 December 2020

The metabolism of phenacetin in patients with renal disease

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12 December 2020

SOME CELLULAR AND METABOLIC CONSIDERATIONS RELATING TO THE ACTION OF QUINIDINE AS A PROTOTYPE ANTIARRHYTHMIC AGENT

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12 December 2020

The absorption and urinary excretion in man of fenfluramine and its main metabolite

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12 December 2020

Quantitative determination of thioridazine and nonconjugated thioridazine metabolites in serum and urine of psychiatric patients

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12 December 2020

Methsuximide overdose. Delayed onset of profound coma

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12 December 2020

Determination of trichloroethanol at therapeutic and overdose levels in blood and urine by electron capture gas chromatography

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12 December 2020

Identification and renal excretion of probenecid metabolites in man

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12 December 2020

Structure-activity relationships in man of cannabis constituents, and homologs and metabolites of delta9-tetrahydrocannabinol

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12 December 2020

Renal Failure, Drug Pharmacokinetics and Drug Action

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12 December 2020

Carbohydrate metabolism in uremia: blood glucose response to sulfonylurea

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Pharmacokinetic model for nalidixic acid in man. II. Parameters for absorption, metabolism, and elimination

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12 December 2020

Gas-chromatographic simultaneous analysis for glutethimide and an active hydroxylated metabolite in tissues, plasma, and urine

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12 December 2020

A comparative evaluation of the hypnotic potency of chloral hydrate and trichloroethanol. I. Studies at the Johns Hopkins University School of Medicine. II. Studies at the St. Louis University School of Medicine. III. Studies at Harvard Medical Scho

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12 December 2020

Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms

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12 December 2020

Effect of Hemodialysis and Renal Failure on Serum and Urine Concentrations of Cephapirin Sodium

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12 December 2020

Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol

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12 December 2020

The metabolic fate of amphetamine in man and other species

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12 December 2020

A specific gas-chromatographic method for the measurement of “steady-state” plasma levels of amitriptyline and nortriptyline in patients

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12 December 2020

Renal clearance of oxipurinol, the chief metabolite of allopurinol

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12 December 2020

The role of the kidney in the elimination of cephapirin in man

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12 December 2020

Metabolism and pharmacokinetics of naloxone

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12 December 2020

The metabolic fate of phenylbutazone (butazolidin) in man

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12 December 2020

The fate of testosterone infused intravenously in man

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12 December 2020

The metabolic fate of codeine in man

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12 December 2020

Hypotensive effect of methyldopa in renal failure associated with hypertension

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12 December 2020

Proceedings: The relationship between fenfluramine and norfenfluramine blood levels and anoretic activity in the rat

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12 December 2020

Mass Spectrometric Characterization of Carbamazepine-10,11-epoxide,a Carbamazepine Metabolite Isolated from Human Urine

1 reference

12 December 2020

Fenfluramine and methylcellulose in the treatment of obesity: the relationship between plasma drug concentrations and therapeutic efficacy

1 reference

12 December 2020

Concentration of glutethimide and associated compounds in huamn serum and cerebrospinal fluid after drug overdose

1 reference

12 December 2020

The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse

1 reference

12 December 2020

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 6. Absorption, excretion and metabolism in man

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12 December 2020

Daunorubicin metabolites in human urine

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12 December 2020

Pharmacokinetics of acetaminophen elimination by anephric patients

1 reference

12 December 2020

Conjugation of methyldopa in renal failure

1 reference

12 December 2020

Antiepileptic Drugs: Biotransformation, Metabolism, and Serum Half-Life

1 reference

12 December 2020

First-pass metabolism of imipramine in man

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12 December 2020

Adriamycin metabolism in man. Evidence from urinary metabolites

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12 December 2020

Warfarin metabolism in man: identification of metabolites in urine

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12 December 2020

The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material

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12 December 2020

Daunorubicin metabolism in acute nonlymphocytic leukemia

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12 December 2020

Editorial: Role of the kidney in the metabolism of calciferol (vitamin D).

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12 December 2020

Clofibrate-induced muscle damage in patients with chronic renal failure

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12 December 2020

Antiarrhythmic efficacy of N-acetylprocainamide in patients with premature ventricular contractions

1 reference

12 December 2020

The possible role of metabolites in therapeutic response to chlorpromazine treatment

1 reference

12 December 2020

The urinary excretion profile of naltrexone and metabolites in man

1 reference

12 December 2020

The fate of acetanilide in man.

1 reference

12 December 2020

Effect of various chlorpromazine metabolites on amphetamine-induced stereotyped behaviour in the rat

1 reference

12 December 2020

Disposition of β-methyldigoxin in man

1 reference

12 December 2020

A comparative pharmacological study of a series of monohydroxylated and methoxylated chlorpromazine derivatives

1 reference

12 December 2020

The Bioavailability of Meperidine Using Urine Assays for Meperidine and Normeperidine

1 reference

12 December 2020

Adriamycin and daunorubicin disposition in the rabbit.

1 reference

12 December 2020

The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine

1 reference

12 December 2020

.beta.-Adrenergic blocking agents. II. Propranolol and related 3-amino-1-naphthoxy-2-propanols

1 reference

12 December 2020

A guide to drug therapy in renal failure.

1 reference

12 December 2020

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. Double-blind cross-over assessments

1 reference

12 December 2020

Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine

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12 December 2020

Effects of two Metabolites of Norethynodrel on Reproductive Performance of Female Rats

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12 December 2020

Metabolic profile of a new immunosuppressive agent, oxisuran: binding, RE stimulation, drug interaction

1 reference

12 December 2020

Plasma concentration of ?-methyldopa and sulphate conjugate after oral administration of methyldopa and intravenous administration of methyldopa and methyldopa hydrochloride ethyl ester

1 reference

12 December 2020

Pharmacokinetics and biotransformation of chlorpropamide in man

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12 December 2020

Effects of 1,25-dihydroxycholecalciferol on calcium absorption, muscle weakness, and bone disease in chronic renal failure.

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12 December 2020

Polymorphic acetylation of procainamide in man

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12 December 2020

Identification of glycinexylidide in patients treated with intravenous lidocaine

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12 December 2020

Isolation and identification of morphine 3- and 6-glucuronides, morphine 3,6-diglucuronide, morphine 3-ethereal sulfate, normorphine, and normorphine 6-glucuronide as morphine metabolites in humans

1 reference

12 December 2020

Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer

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12 December 2020

The etiology of methoxyflurane nephrotoxicity

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12 December 2020

Simultaneous determination of acetylmethanol and its active biotransformation products in human biofluids

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12 December 2020

Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol

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12 December 2020

Urinary Excretion and Plasma Levels of Sulphonamides in Patients with Renal Impairment

1 reference

12 December 2020

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase

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12 December 2020

THE METABOLIC FATE OF C14-LABELED CHLORDIAZEPOXIDE IN MAN, IN THE DOG, AND IN THE RAT

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12 December 2020

Metabolites of probenecid. Chemical, physical, and pharmacological studies

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12 December 2020

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

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12 December 2020

Problems in the bio-assay of orally administered cephaloglycin in biological fluids and method for the detection of its metabolite, desacetylcephaloglycin

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12 December 2020

Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin

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12 December 2020

Pharmacokinetics and metabolism of lidocaine in patients with renal failure

1 reference

12 December 2020

Drug therapy. Serum drug concentrations as therapeutic guides

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12 December 2020

Metabolism and excretion of digitoxin in man

1 reference

12 December 2020

Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man

1 reference

12 December 2020

Spectrofluorodensitometric determination of flurazepam and its major metabolites in blood

1 reference

12 December 2020

ABSORPTION, EXCRETION, AND METABOLISM OF A NEW ANTIBACTERIAL AGENT, NALIDIXIC ACID

1 reference

12 December 2020

Gas chromatography of barbiturates. II. Application to the study of their metabolism and excretion in humans

1 reference

12 December 2020

Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide

1 reference

12 December 2020

Disposition of acetylmethadol in relation to pharmacologic action

1 reference

12 December 2020

Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites

1 reference

12 December 2020

The thermogenic effect and metabolic fate of etiocholanolone in man

1 reference

12 December 2020

Metabolism of Flurazepam, a Benzodiazepine, in Man and Dog

1 reference

12 December 2020

Metabolism, Blood Levels and Rate of Excretion of Acetohexamide in Human Subjects

1 reference

12 December 2020

Metabolism of Oral Contraceptives I. Metabolism of Ethynodiol Diacetate in Women

1 reference

12 December 2020

Glutethimide intoxication: plasma levels of glutethimide and a metabolite in humans, dogs and rats

1 reference

12 December 2020

Ethynodiol diacetate metabolites in human plasma

1 reference

12 December 2020

Warfarin metabolites: the anticoagulant activity and pharmacology of warfarin alcohols

1 reference

12 December 2020

Methoxyflurane nephrotoxicity. A study of dose response in man

1 reference

12 December 2020

Plasma concentrations of fenfluramine and its metabolite, norfenfluramine, after single and repeated oral administration

1 reference

12 December 2020

Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine

1 reference

12 December 2020

An open study of mesoridazine (Serentil) in chronic schizophrenics

1 reference

12 December 2020

A STUDY OF THE PRODUCT OF DEMETHYLATION OF TRIMETHADIONE IN THE CONTROL OF PETIT MAL EPILEPSY

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12 December 2020

Potentiation of Acetohexamide Hypoglycemia by Phenylbutazone

1 reference

12 December 2020

Pharmacokinetic study of a peripheral analgesic, floctafenin, in man, mouse, rat, and dog

1 reference

12 December 2020

Simultaneous determination of trimethadione and its metabolite, dimethadione, by gas-liquid chromatography

1 reference

12 December 2020

A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man

1 reference

12 December 2020

The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man

1 reference

12 December 2020

Acetylation of procainamide in man and its relationship to isonicotinic acid hydrazide acetylation phenotype

1 reference

12 December 2020

Determination of chlordiazepoxide hydrochloride (librium) and its major metabolites in plasma by differential pulse polarography

1 reference

12 December 2020

N-methylated derivatives of barbituric acid, hydantoin and oxazolidinedione used in the treatment of epilepsy

1 reference

12 December 2020

Norethynodrel metabolites in human plasma and urine

1 reference

12 December 2020

METABOLIC PRODUCTS OF QUINIDINE IN URINE OF VOLUNTEER SUBJECTS AND PATIENTS WITH CHRONIC ATRIAL FIBRILLATION

1 reference

12 December 2020

Intravenous Injection in Man of Δ 9 -Tetrahydrocannabinol and 11-OH-Δ 9 -Tetrahydrocannabinol

1 reference

12 December 2020

Plasma levels of methsuximide and N-desmethylmethsuximide during methsuximide therapy

1 reference

12 December 2020

Antihypertensive and noradrenaline-depleting effects of guanethidine metabolites

1 reference

12 December 2020

Pharmacokinetics and biotransformation of chlorpropamide in the rat and dog

1 reference

12 December 2020

The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney

1 reference

12 December 2020

In vitro and in vivo laboratory comparison of cephalothin and desacetylcephalothin

1 reference

12 December 2020

Renal failure and the action of drugs

1 reference

12 December 2020