(Q28338501)

English

Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis

scientific article (publication date: 13 November 1987)

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scholarly article

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Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis (English)

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author name string

A R Mire-Sluis

1

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A V Hoffbrand

2

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R G Wickremasinghe

3

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language of work or name

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publication date

13 November 1987

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Biochemical and Biophysical Research Communications

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148

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1223-31

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3

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Phytohemagglutinin binds to the 20-kDa molecule of the T3 complex

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Mitogens increase phosphorylation of phosphoinositides in thymocytes

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Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores

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Transmembrane ion fluxes during activation of human T lymphocytes: role of Ca2+, Na+/H+ exchange and phospholipid turnover

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Interleukin-2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates

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Inositol trisphosphate and diacylglycerol: two interacting second messengers

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Studies and perspectives of protein kinase C.

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Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C

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T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

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Mitogen treatment of permeabilized human T lymphocytes stimulates rapid tyrosine and serine phosphorylation of a 42 kDa protein

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Growth factors: Mechanism of action and relation to oncogenes

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Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

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Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity

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Fluoroaluminates activate transducin-GDP by mimicking the gamma-phosphate of GTP in its binding site

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Activation of polyphosphoinositide phospholipase C by guanosine 5'-O-(3-thio)triphosphate and fluoroaluminate in membranes prepared from a human T cell leukemia line, JURKAT

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Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

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Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes

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G proteins: transducers of receptor-generated signals

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Identifiers

10.1016/S0006-291X(87)80263-2

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