(Q28343830)

English

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

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scholarly article

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Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP (English)

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author name string

J A Vaccaro

1

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K M Parnell

2

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S A Terezakis

3

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K S Anderson

4

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language of work or name

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publication date

January 2000

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Antimicrobial Agents and Chemotherapy

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44

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1

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217-21

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Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

1 reference

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20 March 2017

Molecular targets for AIDS therapy

1 reference

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20 March 2017

Mechanism and fidelity of HIV reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

20 March 2017

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

29 September 2017

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

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29 September 2017

Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance

1 reference

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29 September 2017

RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates

1 reference

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In search of a selective antiviral chemotherapy.

1 reference

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29 September 2017

Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

1 reference

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29 September 2017

Conformational coupling in DNA polymerase fidelity

1 reference

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29 September 2017

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

1 reference

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29 September 2017

Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections

1 reference

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29 September 2017

HIV resistance to reverse transcriptase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

29 September 2017

Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo

1 reference

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29 September 2017

Retroviral reverse transcriptase: synthesis, structure, and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

29 September 2017

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

29 September 2017

Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

29 September 2017

Prevalence and incidence of resistance to zidovudine and other antiretroviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

2 June 2018

Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

2 June 2018

Clinical pharmacokinetics of stavudine

1 reference

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2 June 2018

Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

2 June 2018

Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89660

2 June 2018

Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase

1 reference

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2 June 2018

Rapid kinetic analysis of mechanochemical adenosinetriphosphatases.

1 reference

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2 June 2018

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

1 reference

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20 June 2018

Initiation of minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase

1 reference

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27 November 2018

Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs

1 reference

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27 November 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

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27 November 2018

A review of abacavir and efavirenz: new antiretroviral drugs to treat HIV-1 infection

1 reference

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12 December 2020

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Molecular mechanisms of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/10602755

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural studies of the anti-HIV agent 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10602755

12 December 2020

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Effect of antiviral drugs and hematopoietic growth factors on in vitro erythropoiesis

1 reference

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Identifiers

10.1128/AAC.44.1.217-221.2000

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